Phenazine 5,10-Dioxide Derivatives as Hypoxic Selective Cytotoxins: Part II. Structure-Activity Relationship Studies

Title: Phenazine 5,10-Dioxide Derivatives as Hypoxic Selective Cytotoxins: Part II. Structure-Activity Relationship Studies

Volume: 2 Issue: 5

Author(s): H. Cerecetto, M. Gonzalez, M. L. Lavaggi, M. A. Aravena, C. Rigol, C. Olea-Azar, A. Azqueta, A. Lopez de Cerain, A. Monge and A. M. Bruno

Affiliation:

Keywords: Phenazine 5, 10-dioxide derivatives, bioreductive compounds, DNA, cyclic voltammetry

Abstract: The synthesis and evaluation as hypoxic selective cytotoxins of new derivatives of 2-amino or 2- hydroxyphenazine 5,10-dioxide are described. The compounds were developed as structural analogs of other bioreductive compounds and its in vitro cytotoxicities on V79 cells under hypoxic and aerobic conditions were determined. To gain insight into its mechanism of action electrochemical behavior, interaction with DNA experiments and QSAR studies were performed.

Cite this article as:

Cerecetto H., Gonzalez M., Lavaggi L. M., Aravena A. M., Rigol C., Olea-Azar C., Azqueta A., Lopez de Cerain A., Monge A. and Bruno M. A., Phenazine 5,10-Dioxide Derivatives as Hypoxic Selective Cytotoxins: Part II. Structure-Activity Relationship Studies, Medicinal Chemistry 2006; 2 (5) . https://dx.doi.org/10.2174/157340606778250207