Synthesis and Biological Evaluation of Coumarin Linked Fluoroquinolones, Phthalimides and Naphthalimides as Potential DNA Gyrase Inhibitors

Title: Synthesis and Biological Evaluation of Coumarin Linked Fluoroquinolones, Phthalimides and Naphthalimides as Potential DNA Gyrase Inhibitors

Volume: 3 Issue: 7

Author(s): A. Kamal, M. Satyanarayana, V. Devaiah, V. Rohini, J. S. Yadav, B. Mullick and V. Nagaraja

Affiliation:

Keywords: Coumarins, Phthalimides, Naphthalimides and Fluoroquinolone DNA gyrase inhibition

Abstract: A hybrid molecule synthesis strategy is employed to develop new molecules with potential antibacterial activity. Three types of coumarin-linked hybrids have been synthesized. The coumarin ring system has been linked to phthalimido, naphthalimido and quinolone moieties at 4-position through piperazino alkane spacers. These compounds have been evaluated for their antibacterial activity. Some of these new hybrids particularly phthalimido and naphthalimido ones have exhibited DNA gyrase inhibition activity.

Cite this article as:

Kamal A., Satyanarayana M., Devaiah V., Rohini V., Yadav S. J., Mullick B. and Nagaraja V., Synthesis and Biological Evaluation of Coumarin Linked Fluoroquinolones, Phthalimides and Naphthalimides as Potential DNA Gyrase Inhibitors, Letters in Drug Design & Discovery 2006; 3 (7) . https://dx.doi.org/10.2174/157018006778194862