Platelet Synthesis of DOPEGAL, the Free Radical Generating Metabolite of Norepinephrine: Potential Target for Protective Therapy in Arteriosclerosis

Title: Platelet Synthesis of DOPEGAL, the Free Radical Generating Metabolite of Norepinephrine: Potential Target for Protective Therapy in Arteriosclerosis

Volume: 3 Issue: 7

Author(s): W. J. Burke, S. W. Li, K. N. Gillespie, H. D. Chung, K. Jagadeesan and J. H. Joist

Affiliation:

Keywords: 3,4-dihydroxyphenylglycolaldehyde, Free radicals, Arteriosclerosis, Platelets, Monoamine oxidase

Abstract: Free radical damage to endothelial cells is implicated in the pathogenesis of arteriosclerosis. We show that platelet monoamine oxidase (MAO) synthesizes 3,4-dihydroxyphenylglycolaldeyde (DOPEGAL), the free radical generating metabolite of norepinephrine (NE). Platelet synthesis of DOPEGAL could contribute to arteriosclerosis and provide a target for protective therapy to prevent arteriosclerosis in medical conditions with elevated NE levels.

Cite this article as:

Burke J. W., Li W. S., Gillespie N. K., Chung D. H., Jagadeesan K. and Joist H. J., Platelet Synthesis of DOPEGAL, the Free Radical Generating Metabolite of Norepinephrine: Potential Target for Protective Therapy in Arteriosclerosis, Letters in Drug Design & Discovery 2006; 3 (7) . https://dx.doi.org/10.2174/157018006778194880