Abstract
5-Lipoxygenase, which leads to the biosynthesis of proinflammatory lipid mediators, is involved in the pathogenesis of cancer. Experimental studies have demonstrated that 5-lipoxygenase inhibitors have antitumoral properties. Here, we describe the compelling evidence that 5-lipoxygenase inhibition is a rational therapy for certain cancers and for adjuvant approaches to cancer therapy.
Keywords: 5-lipoxygenase, Eicosanoids, Cancer therapy, Lipoxygenase inhibitors
Letters in Drug Design & Discovery
Title: Targeting 5-Lipoxygenase Signaling Pathways to Reverse Drug Resistance in Cancer
Volume: 3 Issue: 7
Author(s): Alfonso Catalano and Antonio Procopio
Affiliation:
Keywords: 5-lipoxygenase, Eicosanoids, Cancer therapy, Lipoxygenase inhibitors
Abstract: 5-Lipoxygenase, which leads to the biosynthesis of proinflammatory lipid mediators, is involved in the pathogenesis of cancer. Experimental studies have demonstrated that 5-lipoxygenase inhibitors have antitumoral properties. Here, we describe the compelling evidence that 5-lipoxygenase inhibition is a rational therapy for certain cancers and for adjuvant approaches to cancer therapy.
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Cite this article as:
Catalano Alfonso and Procopio Antonio, Targeting 5-Lipoxygenase Signaling Pathways to Reverse Drug Resistance in Cancer, Letters in Drug Design & Discovery 2006; 3 (7) . https://dx.doi.org/10.2174/157018006778194817
DOI https://dx.doi.org/10.2174/157018006778194817 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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