Abstract
Malignant gliomas are associated with poor prognoses despite surgical, radiation and chemotherapy interventions. Since notable side-effects are associated with each of the aforementioned therapies, the future design of glioma immunotherapy clinical trials will need to address immune modulation at multiple levels for efficacious results. The review discusses emerging data that provides novel insights into immune modulation and their possible implications for immunotherapeutic approaches. The next generation of immunotherapy is largely focused on improving immune effector targeting and directing the tumor immune microenvironment to work synergistically with systematic immune activation.
Keywords: Microglia, Antigen presenting cells, Glioblastoma multiforme, Dendritic cell, Regulatory T cell, Central nervous system
Letters in Drug Design & Discovery
Title: The Role of Glioma Microenvironment in Immune Modulation: Potential Targets for Intervention
Volume: 3 Issue: 7
Author(s): Mahua Dey, S. Farzana Hussain and Amy B. Heimberger
Affiliation:
Keywords: Microglia, Antigen presenting cells, Glioblastoma multiforme, Dendritic cell, Regulatory T cell, Central nervous system
Abstract: Malignant gliomas are associated with poor prognoses despite surgical, radiation and chemotherapy interventions. Since notable side-effects are associated with each of the aforementioned therapies, the future design of glioma immunotherapy clinical trials will need to address immune modulation at multiple levels for efficacious results. The review discusses emerging data that provides novel insights into immune modulation and their possible implications for immunotherapeutic approaches. The next generation of immunotherapy is largely focused on improving immune effector targeting and directing the tumor immune microenvironment to work synergistically with systematic immune activation.
Export Options
About this article
Cite this article as:
Dey Mahua, Farzana Hussain S. and Heimberger B. Amy, The Role of Glioma Microenvironment in Immune Modulation: Potential Targets for Intervention, Letters in Drug Design & Discovery 2006; 3 (7) . https://dx.doi.org/10.2174/157018006778194844
DOI https://dx.doi.org/10.2174/157018006778194844 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Development of Linker-Conjugated Nanosize Lipid Vesicles: A Strategy for Cell Selective Treatment in Breast Cancer
Current Cancer Drug Targets Targeting Heat Shock Proteins 70/90 and Proteasome for Cancer Therapy
Current Medicinal Chemistry MiR-125b Inhibits Cell Proliferation and Induces Apoptosis in Human Colon Cancer SW480 Cells <i>via</i> Targeting STAT3
Recent Patents on Anti-Cancer Drug Discovery Role of Mu and Delta Opioid Receptors in Alcohol Drinking Behaviour
Current Drug Abuse Reviews Radiation Induced Non-targeted Response: Mechanism and Potential Clinical Implications
Current Molecular Pharmacology Pigment Epithelium-Derived Factor Prevents Melanoma Growth via Angiogenesis Inhibition
Current Pharmaceutical Design Recent Progress on Antifungal Drug Development
Current Pharmaceutical Biotechnology Targeting Neuronal Nicotinic Receptors in Cancer: New Ligands and Potential Side-Effects
Recent Patents on Anti-Cancer Drug Discovery Toll Like Receptors Signaling Pathways as a Target for Therapeutic Interventions
Current Signal Transduction Therapy Tumor Vasculature Targeting Through NGR Peptide-Based Drug Delivery Systems
Current Pharmaceutical Biotechnology Stem Cells as In Vitro Models of Disease
Current Stem Cell Research & Therapy Sirtuins Family- Recent Development as a Drug Target for Aging, Metabolism, and Age Related Diseases
Current Drug Targets Pharmacological Aspects of the Enzastaurin-Pemetrexed Combination in Non-Small Cell Lung Cancer (NSCLC)
Current Drug Targets Targeted Liposomal Drug Delivery in Cancer
Current Pharmaceutical Design Upregulation of Focal Adhesion Kinase by 14-3-3ε via NFκB Activation in Hepatocellular Carcinoma
Anti-Cancer Agents in Medicinal Chemistry Evaluation of Skin Permeability of Resveratrol Loaded Liposomes and Nanostructured Lipid Carriers using a Skin Mimic Artificial Membrane (skin-PAMPA)
Drug Delivery Letters Thioredoxin, Glutathione and Related Molecules in Tumors of the Nervous System
Current Medicinal Chemistry Small-molecule Inhibitors of Epigenetic Mutations as Compelling Drugtargets for Myelodysplastic Syndromes
Current Cancer Drug Targets Drug-Lipid Membrane Interaction Mechanisms Revealed Through Molecular Simulations
Current Physical Chemistry Use of Topiceuticals (Topically Applied, Peripherally Acting Drugs) in the Treatment of Chronic Pain
Current Drug Therapy