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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

A Silica-Supported Copper(I) Catalyzed Sonogashira Coupling Reaction

Author(s): Lei Wang, Pinhua Li and Liyuan Zhang

Volume 3, Issue 4, 2006

Page: [282 - 285] Pages: 4

DOI: 10.2174/157017806776114559

Price: $65

Abstract

An immobilization of copper(I) in organic-inorganic hybrid materials catalyzed Sonogashira coupling reaction was developed. Terminal alkynes reacted with aryl iodides and aryl bromides in the presence of 3-(2-aminoethylamino)propyl functionalized silica gel immobilized copper(I) catalyst, triphenylphosphine and potassium carbonate in DMF. The reactions generated the corresponding cross-coupling products in good to excellent yields. Furthermore, silica-supported copper was recovered and recycled by a simple filtration of the reaction solution and used for six consecutive trials without decreases in activity.

Keywords: heterogeneous catalyst, immobilization of copper(I), organic-inorganic hybrid material, Sonogashira coupling reaction


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