A Mild and Chemoselective Solvent-Free Method for the Synthesis of N-Aryl and N-Alkylsulfonamides

Title: A Mild and Chemoselective Solvent-Free Method for the Synthesis of N-Aryl and N-Alkylsulfonamides

Volume: 3 Issue: 3

Author(s): Ahmad R. Massah, Foad Kazemi, Davood Azadi, Shakiba Farzaneh, Hamid Aliyan, Hamid J. Naghash and Ahmad. R. Momeni

Affiliation:

Keywords: Chemoselective, Solvent-free, N-arylsulfonamide, N-alkylsulfonamide

Abstract: In this study, a general, mild and convenient solvent-free method has been developed for the synthesis of various N-aryl and N-alkylsulfonamides. A variety of sulfonamides were prepared at room temperature in high yield and purity. Selective sulfonylation of electron rich amines in the presence of electron poor ones and also chemoselective sulfonylation of amino group in amino alcohols and amino phenols are the noteworthy advantages of this method.

Cite this article as:

Massah R. Ahmad, Kazemi Foad, Azadi Davood, Farzaneh Shakiba, Aliyan Hamid, Naghash J. Hamid and Momeni R. Ahmad., A Mild and Chemoselective Solvent-Free Method for the Synthesis of N-Aryl and N-Alkylsulfonamides, Letters in Organic Chemistry 2006; 3 (3) . https://dx.doi.org/10.2174/157017806775789886