Mono- and Bis-Pyrimido[1,2-a]benzimidazoles: Alum Catalyzed Regioselective Three- or Pseudo Five-Component Reaction of 2-Aminobenzimidazole with Aldehyde and Malononitrile

Title: Mono- and Bis-Pyrimido[1,2-a]benzimidazoles: Alum Catalyzed Regioselective Three- or Pseudo Five-Component Reaction of 2-Aminobenzimidazole with Aldehyde and Malononitrile

Volume: 8 Issue: 9

Author(s): Ali R. Karimi and Fahimeh Bayat

Affiliation:

Keywords: 2-Aminobenzimidazole, alum, multicomponent reaction, pyrimido[1,2-a]benzimidazole, regioselectivity, benzo-fused imidazoles, anticancer, antihistaminic, antifungal, antibacterial

Abstract: A series of mono- and bis-pyrimido-[1,2-a]benzimidazole derivatives is synthesized by the regioselective multicomponent condensation reaction of aldehyde and malononitrile with 2-aminobenzimidazole in the presence of alum as a recyclable and efficient catalyst for this condensation.

Cite this article as:

R. Karimi Ali and Bayat Fahimeh, Mono- and Bis-Pyrimido[1,2-a]benzimidazoles: Alum Catalyzed Regioselective Three- or Pseudo Five-Component Reaction of 2-Aminobenzimidazole with Aldehyde and Malononitrile, Letters in Organic Chemistry 2011; 8 (9) . https://dx.doi.org/10.2174/157017811799304368