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Current Organic Chemistry

Editor-in-Chief

ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Applications of the Nicholas Reaction in the Synthesis of Natural Products

Author(s): Nina Kann

Volume 16, Issue 3, 2012

Page: [322 - 334] Pages: 13

DOI: 10.2174/138527212799499949

Price: $65

Abstract

The Nicholas reaction involves the treatment of a cobalt carbonyl-stabilized propargylic cation with a variety of nucleophiles to form a new carbon-carbon or carbon-heteroatom bond. Several features of this reaction make it especially well suited for applications in natural product synthesis, in particular when cyclic and polycyclic target molecules are involved. This review summarizes the results in this area from the last ten years, including approaches towards terpenes, alkaloids and marine natural products.

Keywords: Alkaloid, cobalt alkyne complex, marine polyether, natural product synthesis, Nicholas reaction, terpene


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