Abstract
The Nicholas reaction involves the treatment of a cobalt carbonyl-stabilized propargylic cation with a variety of nucleophiles to form a new carbon-carbon or carbon-heteroatom bond. Several features of this reaction make it especially well suited for applications in natural product synthesis, in particular when cyclic and polycyclic target molecules are involved. This review summarizes the results in this area from the last ten years, including approaches towards terpenes, alkaloids and marine natural products.
Keywords: Alkaloid, cobalt alkyne complex, marine polyether, natural product synthesis, Nicholas reaction, terpene
Current Organic Chemistry
Title: Applications of the Nicholas Reaction in the Synthesis of Natural Products
Volume: 16 Issue: 3
Author(s): Nina Kann
Affiliation:
Keywords: Alkaloid, cobalt alkyne complex, marine polyether, natural product synthesis, Nicholas reaction, terpene
Abstract: The Nicholas reaction involves the treatment of a cobalt carbonyl-stabilized propargylic cation with a variety of nucleophiles to form a new carbon-carbon or carbon-heteroatom bond. Several features of this reaction make it especially well suited for applications in natural product synthesis, in particular when cyclic and polycyclic target molecules are involved. This review summarizes the results in this area from the last ten years, including approaches towards terpenes, alkaloids and marine natural products.
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Cite this article as:
Kann Nina, Applications of the Nicholas Reaction in the Synthesis of Natural Products, Current Organic Chemistry 2012; 16 (3) . https://dx.doi.org/10.2174/138527212799499949
DOI https://dx.doi.org/10.2174/138527212799499949 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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