Abstract
Fatty acid biosynthesis is essential for bacterial survival. In recent years, components of this biosynthetic pathway have aroused wide concern. β-Ketoacyl-acyl carrier protein synthase III (FabH) is a particularly attractive target which catalyzes the initial step of fatty acid biosynthesis. In this review, fatty acid biosynthesis, recent advances in the research of FabH as well as related inhibitors are reviewed. Finally, we also discuss the prospect and developmental trend of FabH inhibitors as anti-bacterial agents.
Keywords: anti-bacterial agents, fatty acid synthase (FAS), FabH, FabH inhibitors, Alkyl-CoA disulfides, Thiolactomycin derivatives, 1,2-Dithiole-3-(thi)ones derivatives, Dithiole-3-(thi)ones derivatives, Cerulenin derivatives, Indole derivatives, Benzoylaminobenzoic acid derivatives, Alkylsulfonyl derivatives, Thiazolidine-2-one 1, 1-dioxide derivatives
Current Medicinal Chemistry
Title: Advances in the Research of β-Ketoacyl-ACP Synthase III (FabH) Inhibitors
Volume: 19 Issue: 8
Author(s): H. -J. Zhang, Z. -L. Li and H. -L. Zhu
Affiliation:
Keywords: anti-bacterial agents, fatty acid synthase (FAS), FabH, FabH inhibitors, Alkyl-CoA disulfides, Thiolactomycin derivatives, 1,2-Dithiole-3-(thi)ones derivatives, Dithiole-3-(thi)ones derivatives, Cerulenin derivatives, Indole derivatives, Benzoylaminobenzoic acid derivatives, Alkylsulfonyl derivatives, Thiazolidine-2-one 1, 1-dioxide derivatives
Abstract: Fatty acid biosynthesis is essential for bacterial survival. In recent years, components of this biosynthetic pathway have aroused wide concern. β-Ketoacyl-acyl carrier protein synthase III (FabH) is a particularly attractive target which catalyzes the initial step of fatty acid biosynthesis. In this review, fatty acid biosynthesis, recent advances in the research of FabH as well as related inhibitors are reviewed. Finally, we also discuss the prospect and developmental trend of FabH inhibitors as anti-bacterial agents.
Export Options
About this article
Cite this article as:
-J. Zhang H., -L. Li Z. and -L. Zhu H., Advances in the Research of β-Ketoacyl-ACP Synthase III (FabH) Inhibitors, Current Medicinal Chemistry 2012; 19 (8) . https://dx.doi.org/10.2174/092986712799320484
DOI https://dx.doi.org/10.2174/092986712799320484 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the treatment of chronic inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
The Newborn Individualized Developmental Care and Assessment Program (NIDCAP) with Kangaroo Mother Care (KMC): Comprehensive Care for Preterm Infants
Current Women`s Health Reviews Antiviral Activity of Phytochemicals: A Comprehensive Review
Mini-Reviews in Medicinal Chemistry Lithium and its Neuroprotective and Neurotrophic Effects: Potential Treatment for Post-Ischemic Stroke Sequelae
Current Drug Targets Evaluation of the Risk/Benefit Ratio of Old and New Anti-Inflammatory Drugs
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Commentary: Olfactory Dysfunction in Parkinson’s Disease
CNS & Neurological Disorders - Drug Targets Interview: Dr. Muin J. Khoury Discusses the Future of Public Health Genomics and why it Matters for Personalized Medicine and Global Health
Current Pharmacogenomics and Personalized Medicine LRP/LR as an Alternative Promising Target in Therapy of Prion Diseases, Alzheimers Disease and Cancer
Infectious Disorders - Drug Targets Human Lipoxygenase: Developments in its Structure, Function, Relevance to Diseases and Challenges in Drug Development
Current Medicinal Chemistry Recent Development in Fluorescent Probes for Copper Ion Detection
Current Topics in Medicinal Chemistry Molecular Manipulation of G Protein coupled Receptors A New Avenue into Drug Discovery
Current Medicinal Chemistry Global Expression Studies of Schizophrenic Brain: A Meta-Analysis Study Linking Neurological Immune System with Psychological Disorders
CNS & Neurological Disorders - Drug Targets The Future of Neuroregenerative Therapy for Parkinson’s Disease
Current Tissue Engineering (Discontinued) Clinical and Rehabilitative Management of Retinitis Pigmentosa:Up-to-Date
Current Genomics New Insights in Drug-Induced Mitochondrial Toxicity
Current Pharmaceutical Design Mitochondria as a Therapeutic Target for Aging and Neurodegenerative Diseases
Current Alzheimer Research Current Developments for the Diagnosis and Treatment of Irritable Bowel Syndrome
Current Pharmaceutical Design Aripiprazole in Children and Adolescents with Schizophrenia
Current Psychopharmacology Carbon Nano Tubes: Novel Drug Delivery System in Amelioration of Alzheimer’s Disease
Combinatorial Chemistry & High Throughput Screening Acellular Spinal Cord Scaffold Implantation Promotes Vascular Remodeling with Sustained Delivery of VEGF in a Rat Spinal Cord Hemisection Model
Current Neurovascular Research Lung Ultrasound in the Critically Ill Neonate
Current Pediatric Reviews