Abstract
Aging and its related diseases are severe issues in modern society. Many efforts have been made to understand the mechanisms of aging and to find the ways to prevent age-related diseases. Identifying the compounds targeting agingrelated signals is a challenging work because there are so many proteins and signals involved. Recently, alone with the progresses in high throughput screening (HTS) technology, increasing numbers of small molecules targeting aging-related pathologic processes have been identified. In this review, we introduce the basic workflow, classification and assay strategies of HTS technology, and sort out known small molecules identified via HTS technology by their roles in aging related diseases, such as neural degenerative diseases, diabetes and tumors. Given the fact that application of HTS on aging research is still at an early stage, we also summarize the cellular mechanisms about aging process, paralleled with the compounds which can modulate the functions of proteins important for aging signals. Finally, we briefly discuss some advanced HTS technologies for their potent applications on the discovery of anti-aging compounds. The main purpose of this review is to provide updated and useful information to those who are interested in pharmacology and HTS technology, but not familiar with aging biology, or vice versa.
Keywords: Aging, compound, high throughput screening, protein, age-related diseases, cardiovascular disorders, tumors, cellular macromolecules, neural degeneration, fluorescence-tagged assays, Scintillation proximity assay (SPA), high sensitivity, specificity, proteins, affinity, homogeneous assay, fluorescence resonance energy transfer, fluorescence polarization, fluorescence correlation spectroscopy, cell-based screening, drug screening, cell viability, proliferation, apoptosis, neurons
Combinatorial Chemistry & High Throughput Screening
Title: High Throughput Screening Technology and the Small Molecules Modulating Aging Related Signals
Volume: 15 Issue: 3
Author(s): Chunfen Mo, Wei Zhang, Luhong Liu, Ling Wang and Hengyi Xiao
Affiliation:
Keywords: Aging, compound, high throughput screening, protein, age-related diseases, cardiovascular disorders, tumors, cellular macromolecules, neural degeneration, fluorescence-tagged assays, Scintillation proximity assay (SPA), high sensitivity, specificity, proteins, affinity, homogeneous assay, fluorescence resonance energy transfer, fluorescence polarization, fluorescence correlation spectroscopy, cell-based screening, drug screening, cell viability, proliferation, apoptosis, neurons
Abstract: Aging and its related diseases are severe issues in modern society. Many efforts have been made to understand the mechanisms of aging and to find the ways to prevent age-related diseases. Identifying the compounds targeting agingrelated signals is a challenging work because there are so many proteins and signals involved. Recently, alone with the progresses in high throughput screening (HTS) technology, increasing numbers of small molecules targeting aging-related pathologic processes have been identified. In this review, we introduce the basic workflow, classification and assay strategies of HTS technology, and sort out known small molecules identified via HTS technology by their roles in aging related diseases, such as neural degenerative diseases, diabetes and tumors. Given the fact that application of HTS on aging research is still at an early stage, we also summarize the cellular mechanisms about aging process, paralleled with the compounds which can modulate the functions of proteins important for aging signals. Finally, we briefly discuss some advanced HTS technologies for their potent applications on the discovery of anti-aging compounds. The main purpose of this review is to provide updated and useful information to those who are interested in pharmacology and HTS technology, but not familiar with aging biology, or vice versa.
Export Options
About this article
Cite this article as:
Mo Chunfen, Zhang Wei, Liu Luhong, Wang Ling and Xiao Hengyi, High Throughput Screening Technology and the Small Molecules Modulating Aging Related Signals, Combinatorial Chemistry & High Throughput Screening 2012; 15 (3) . https://dx.doi.org/10.2174/138620712799218581
DOI https://dx.doi.org/10.2174/138620712799218581 |
Print ISSN 1386-2073 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5402 |
Call for Papers in Thematic Issues
Artificial Intelligence Methods for Biomedical, Biochemical and Bioinformatics Problems
Recently, a large number of technologies based on artificial intelligence have been developed and applied to solve a diverse range of problems in the areas of biomedical, biochemical and bioinformatics problems. By utilizing powerful computing resources and massive amounts of data, methods based on artificial intelligence can significantly improve the ...read more
Eco-friendly Agents for Biological Control of Pathogenic Diseases
The discovery of an alternative biological approach to disease management includes work on medicinal products derived from natural sources as a starting point for the development of eco-friendly agents for these diseases and the injuries they cause, as well as reducing human contact with hazardous chemicals and their residues. We ...read more
Emerging trends in diseases mechanisms, noble drug targets and therapeutic strategies: focus on immunological and inflammatory disorders
Recently infectious and inflammatory diseases have been a key concern worldwide due to tremendous morbidity and mortality world Wide. Recent, nCOVID-9 pandemic is a good example for the emerging infectious disease outbreak. The world is facing many emerging and re-emerging diseases out breaks at present however, there is huge lack ...read more
Exploring Spectral Graph Theory in Combinatorial Chemistry
Scope of the Thematic Issue: Combinatorial chemistry involves the synthesis and analysis of a large number of diverse compounds simultaneously. Traditional methods rely on brute force experimentation, which can be time-consuming and resource-intensive. Spectral Graph Theory, a branch of mathematics dealing with the properties of graphs in relation to the ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Targeting Multiplicity: The Key Factor for Anti-Cancer Nanoparticles
Current Medicinal Chemistry Anal Cancer: Focus on HIV-Positive Patients in the HAART Era
Current HIV Research Testicular Germ Cell Tumors: A Paradigm for the Successful Treatment of Solid Tumor Stem Cells
Current Cancer Therapy Reviews Recent Patents Relating to Tumor Suppressor Genes
Recent Patents on DNA & Gene Sequences Advances of Phenoxazines: Synthesis, Reactivity and Their Medicinal Applications
Current Medicinal Chemistry Analysis of Codon Usage Patterns in the Human Papillomavirus Oncogenes
Current Bioinformatics Structure and Functional Relationships of Hsp90
Current Cancer Drug Targets Malignant Mesothelioma: Cell Survival Pathways and Radiation Therapy
Current Respiratory Medicine Reviews PEDF & Stem Cells: Niche vs. Nurture
Current Drug Delivery Vascular Endothelial Growth Factor and Diabetic Retinopathy: Role of Oxidative Stress
Current Drug Targets Novel Insights in Molecular Mechanisms of CLL
Current Pharmaceutical Design Mining the Adenovirus "Virome" for Systemic Oncolytics
Current Pharmaceutical Biotechnology Editorial [Hot Topic: Hydrolase Versus Other Functions of Members of the Alpha/Beta-Hydrolase Fold Superfamily of Proteins (Guest Editor: Pascale Marchot and Arnaud Chatonnet)]
Protein & Peptide Letters Targeted Gene Therapy for Ovarian Cancer
Current Gene Therapy HPV-mediated Cervical Cancer: A Systematic Review on Immunological Basis, Molecular Biology, and Immune Evasion Mechanisms
Current Drug Targets The Pathophysiological Role of PEDF in Bone Diseases
Current Molecular Medicine Enzymatic Activity and Protein Interactions in Alpha/Beta Hydrolase Fold Proteins: Moonlighting Versus Promiscuity
Protein & Peptide Letters Gene Therapy in Plastic and Reconstructive Surgery
Current Gene Therapy Impact of Cellular Senescence in Aging and Cancer
Current Pharmaceutical Design Natural Product Inhibitors of Hsp90: Potential Leads for Drug Discovery
Mini-Reviews in Medicinal Chemistry