Abstract
The existence of functional NT/dopamine interactions in the central nervous system has been extensively documented. Among others, a possible molecular mechanism underlying the NT-induced modulation of dopamine release is a direct antagonistic NTS1/D2 receptor interaction. More recently, neurochemical experiments also supported the existence of a possible interaction between NT and N-methyl-d-aspartate (NMDA) receptors. In particular, it has been suggested that NT, by amplifying NMDA receptor signaling, could be involved in neurodegeneration.
The present article attempts to provide a summary of current knowledge, mainly emerging from our studies, on the existence of receptor-receptor interactions between NT receptor subtype 1 (NTS1) and dopamine D2 or NMDA receptors in the brain. Special emphasis is placed on the pre and post-synaptic neurochemical mechanisms possibly underlying the involvement of these interactions in the physiopathology of schizophrenia and acute neurodegenerative disorders.
Keywords: Neurotensin analogues, SR48692, NTS1 receptor, Antipsychotic drugs, Dopamine, Receptor heteromers, Microdialysis, Nucleus accumbens, Cerebral ischemia, Glutamate, Structure-activity relationship
Current Medicinal Chemistry
Title: Relevance of Dopamine D2/Neurotensin NTS1 and NMDA/Neurotensin NTS1 Receptor Interaction in Psychiatric and Neurodegenerative Disorders
Volume: 19 Issue: 3
Author(s): S. Tanganelli, T. Antonelli, M. C. Tomasini, S. Beggiato, K. Fuxe and L. Ferraro
Affiliation:
Keywords: Neurotensin analogues, SR48692, NTS1 receptor, Antipsychotic drugs, Dopamine, Receptor heteromers, Microdialysis, Nucleus accumbens, Cerebral ischemia, Glutamate, Structure-activity relationship
Abstract: The existence of functional NT/dopamine interactions in the central nervous system has been extensively documented. Among others, a possible molecular mechanism underlying the NT-induced modulation of dopamine release is a direct antagonistic NTS1/D2 receptor interaction. More recently, neurochemical experiments also supported the existence of a possible interaction between NT and N-methyl-d-aspartate (NMDA) receptors. In particular, it has been suggested that NT, by amplifying NMDA receptor signaling, could be involved in neurodegeneration.
The present article attempts to provide a summary of current knowledge, mainly emerging from our studies, on the existence of receptor-receptor interactions between NT receptor subtype 1 (NTS1) and dopamine D2 or NMDA receptors in the brain. Special emphasis is placed on the pre and post-synaptic neurochemical mechanisms possibly underlying the involvement of these interactions in the physiopathology of schizophrenia and acute neurodegenerative disorders.
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Cite this article as:
Tanganelli S., Antonelli T., C. Tomasini M., Beggiato S., Fuxe K. and Ferraro L., Relevance of Dopamine D2/Neurotensin NTS1 and NMDA/Neurotensin NTS1 Receptor Interaction in Psychiatric and Neurodegenerative Disorders, Current Medicinal Chemistry 2012; 19 (3) . https://dx.doi.org/10.2174/092986712803414268
DOI https://dx.doi.org/10.2174/092986712803414268 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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