Abstract
During the last years, there have been a number of reports that prove involvement of mitochondria in the pathogenesis of variety of disorders including cancer and neurodegenerative diseases. Alteration of vital mitochondrial functions - production of ATP, calcium buffering capacity, abnormal production of reactive oxygen species, can be potentially responsible for pathogenesis of cancer and neurodegenerative diseases. Involvement of mitochondria in various types of cell death makes them attractive targets for tumor cell elimination. This review describes the role of mitochondria in tumor cells and how targeting of mitochondria can be used as a tool in fighting cancer.
Keywords: Cancer, apoptosis, necrosis, mitochondria, calcium, permeability transition, Bcl-2, reactive oxygen species, tumor cell, glycolysis
Current Pharmaceutical Design
Title: Targeting Mitochondria in Fighting Cancer
Volume: 17 Issue: 36
Author(s): Vladimir Gogvadze
Affiliation:
Keywords: Cancer, apoptosis, necrosis, mitochondria, calcium, permeability transition, Bcl-2, reactive oxygen species, tumor cell, glycolysis
Abstract: During the last years, there have been a number of reports that prove involvement of mitochondria in the pathogenesis of variety of disorders including cancer and neurodegenerative diseases. Alteration of vital mitochondrial functions - production of ATP, calcium buffering capacity, abnormal production of reactive oxygen species, can be potentially responsible for pathogenesis of cancer and neurodegenerative diseases. Involvement of mitochondria in various types of cell death makes them attractive targets for tumor cell elimination. This review describes the role of mitochondria in tumor cells and how targeting of mitochondria can be used as a tool in fighting cancer.
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Cite this article as:
Gogvadze Vladimir, Targeting Mitochondria in Fighting Cancer, Current Pharmaceutical Design 2011; 17 (36) . https://dx.doi.org/10.2174/138161211798764933
DOI https://dx.doi.org/10.2174/138161211798764933 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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