Abstract
Contrary to the Classical Greek poet Archilochus phrase “The fox knows many things but the hedgehog knows one big thing”, the Hedgehog (HH) signaling pathway knows at least 3 ways to promote or support carcinogenesis. In this review, we provide a summary of the HH signaling pathway, and detail the clinical relevance and treatment of patients. Finally, future directions in exploiting this promising pathway will be addressed.
Keywords: Hedgehog pathway, cancer, treatment, mutation, autocrine, paracrine, signaling, clinical trial, carcinogenesis, PTCH1
Current Drug Targets
Title: The Hedgehog Knows Many Tricks
Volume: 12 Issue: 14
Author(s): Glen J. Weiss, Alain C. Mita and Daniel D. Von Hoff
Affiliation:
Keywords: Hedgehog pathway, cancer, treatment, mutation, autocrine, paracrine, signaling, clinical trial, carcinogenesis, PTCH1
Abstract: Contrary to the Classical Greek poet Archilochus phrase “The fox knows many things but the hedgehog knows one big thing”, the Hedgehog (HH) signaling pathway knows at least 3 ways to promote or support carcinogenesis. In this review, we provide a summary of the HH signaling pathway, and detail the clinical relevance and treatment of patients. Finally, future directions in exploiting this promising pathway will be addressed.
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Cite this article as:
J. Weiss Glen, C. Mita Alain and D. Von Hoff Daniel, The Hedgehog Knows Many Tricks, Current Drug Targets 2011; 12 (14) . https://dx.doi.org/10.2174/138945011798829429
DOI https://dx.doi.org/10.2174/138945011798829429 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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