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Cardiovascular & Hematological Disorders-Drug Targets

Editor-in-Chief

ISSN (Print): 1871-529X
ISSN (Online): 2212-4063

Synthesis and Antihypertensive Action of New Imidazo[1,2-a]pyridine Derivatives , non Peptidic Angiotensin II Receptor Antagonists

Author(s): Sonia Laneri, Cristina Di Ronza, Antonietta Bernardi, Carmine Ostacolo, Antonia Sacchi, Carmela Cervone, Michele D'Amico, Clara Di Filippo, Maria Letizia Trincavelli, Anna Panighini and Claudia Martini

Volume 11, Issue 2, 2011

Page: [87 - 96] Pages: 10

DOI: 10.2174/187152911798347016

Price: $65

Abstract

The synthesis and antihypertensive activity of a group of imidazo[1,2-a]pyridine is described. New synthesized compound have been tested both in vivo and in vitro as antagonists on Angiotensin AT1 receptor, and compared to Losartan, used as reference drug. Binding assay an Angiotensin AT1 receptor were carried on as well. Compounds 6b and 6g showed a potent antihypertensive activity and an high affinity on AT1 receptor.

Keywords: AngII AT1 receptor antagonists, antihypertensive in vivo and in vitro activity, imidazo[1,2-a]pyridine, Synthesis and Antihypertensive Action of New Imidazo[1,2-a]pyridine Derivatives, non Peptidic Angiotensin II Receptor, Antagonists, linear octapeptide angiotensin

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