Abstract
Impaired diabetic wound healing (WH) constitutes a serious diabetic complication with increased morbidity, mortality and health expenditure. The exact pathogenetic mechanisms have not been fully clarified. A variety of hyperglycemia and oxidative stress related factors, have been proposed, including advanced glycaction end products (AGE). The existing literature data, support the role of AGE in the pathogenesis of diabetic complications, namely micro- and macro- angiopathy which underlie delayed diabetic WH. In addition, a large body of evidence support a direct negative effect of AGE in the WH process by their interference with various components involved in the cascade following skin injury. Endogenously formed or exogenously derived AGE, in a similar manner, affect negatively the WH process in diabetes. It is obvious that further studies are needed to clarify the exact role of AGE in the impaired diabetic WH and offer possible new therapeutic strategies
Keywords: Advanced glycation end products, AGE, Ncarboxymethyllysine (CML), Methylglyoxal (MG), Diabetic wound healing, Oxidative stress, Inflammation, LDL, Diabetic Nephropathy, Diabetic Retinopathy
Current Diabetes Reviews
Title: Glycoxidation and Wound Healing in Diabetes: An Interesting Relationship
Volume: 7 Issue: 6
Author(s): Melpomeni Peppa and Sotirios A. Raptis
Affiliation:
Keywords: Advanced glycation end products, AGE, Ncarboxymethyllysine (CML), Methylglyoxal (MG), Diabetic wound healing, Oxidative stress, Inflammation, LDL, Diabetic Nephropathy, Diabetic Retinopathy
Abstract: Impaired diabetic wound healing (WH) constitutes a serious diabetic complication with increased morbidity, mortality and health expenditure. The exact pathogenetic mechanisms have not been fully clarified. A variety of hyperglycemia and oxidative stress related factors, have been proposed, including advanced glycaction end products (AGE). The existing literature data, support the role of AGE in the pathogenesis of diabetic complications, namely micro- and macro- angiopathy which underlie delayed diabetic WH. In addition, a large body of evidence support a direct negative effect of AGE in the WH process by their interference with various components involved in the cascade following skin injury. Endogenously formed or exogenously derived AGE, in a similar manner, affect negatively the WH process in diabetes. It is obvious that further studies are needed to clarify the exact role of AGE in the impaired diabetic WH and offer possible new therapeutic strategies
Export Options
About this article
Cite this article as:
Peppa Melpomeni and A. Raptis Sotirios, Glycoxidation and Wound Healing in Diabetes: An Interesting Relationship, Current Diabetes Reviews 2011; 7 (6) . https://dx.doi.org/10.2174/157339911797579188
DOI https://dx.doi.org/10.2174/157339911797579188 |
Print ISSN 1573-3998 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6417 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Protein Misfolding in Disease and Small Molecule Therapies
Current Topics in Medicinal Chemistry NSAIDs Induced Regulation of Alternatively Spliced Transcript Isoforms: Possible Role in Cancer and Alzheimer Disease
Current Cancer Drug Targets Frontotemporal Dementia Caused by CHMP2B Mutations
Current Alzheimer Research Molecular Structure of Ionotropic Glutamate Receptors
Current Medicinal Chemistry Glutamate Transporter GLT-1 as a Therapeutic Target for Substance Use Disorders
CNS & Neurological Disorders - Drug Targets Role of Prostaglandins in Multiple Sclerosis
Current Pharmaceutical Design Role of Methylene Blue in Trauma Neuroprotection and Neuropsychiatric Diseases
CNS & Neurological Disorders - Drug Targets Diabetic Neuropathy: Update on Pathophysiological Mechanism and the Possible Involvement of Glutamate Pathways
Current Diabetes Reviews Nicotine-Derived Compounds as Therapeutic Tools Against Post-Traumatic Stress Disorder
Current Pharmaceutical Design Combination of Naringenin and Lisinopril Ameliorates Nephropathy in Type-1 Diabetic Rats
Endocrine, Metabolic & Immune Disorders - Drug Targets Does More MnSOD Mean More Hydrogen Peroxide?
Anti-Cancer Agents in Medicinal Chemistry Applications of iTRAQ and TMT Labeling Techniques to the Study of Neurodegenerative Diseases
Current Protein & Peptide Science No Significant Effect of 7,8-Dihydroxyflavone on APP Processing and Alzheimer-Associated Phenotypes
Current Alzheimer Research At the “Junction” of Spinal Muscular Atrophy Pathogenesis: The Role of Neuromuscular Junction Dysfunction in SMA Disease Progression
Current Molecular Medicine Pharmacologic Targeting of Endothelial Progenitor Cells
Cardiovascular & Hematological Disorders-Drug Targets Cardiac Effects of HDL and Its Components on Diabetic Cardiomyopathy
Endocrine, Metabolic & Immune Disorders - Drug Targets Astrocytes Pathology in ALS: A Potential Therapeutic Target?
Current Pharmaceutical Design Transient Responses Via Regulation of mRNA Stability as an Immunological Strategy for Countering Infectious Diseases
Infectious Disorders - Drug Targets Endothelium as a Therapeutic Target in Diabetes Mellitus: From Basic Mechanisms to Clinical Practice
Current Medicinal Chemistry Regulation of the Sodium-Phosphate Cotransporter Pit-1 and its Role in Vascular Calcification
Current Vascular Pharmacology