Recent Advance in Aminopeptidase N (APN/CD13) Inhibitor Research

X.      Zhang; H.      Fang; J.      Zhang; Y.      Yuan; W.      Xu

Abstract

APN is an important zinc dependent metallo-exopeptidase, which can degrade the extracellular matrix, and plays an important role in tumor invasion, metastasis and angiogenesis. it has been considered as a suitable target for anti-cancer drug design. Recently, research of structure-based APN inhibitors is becoming an interesting field, and many APN inhibitors have been reported. Here we review a series of APN inhibitors and the recent progress in this field.

Keywords: Aminopeptidase N, rational drug design, inhibitors, peptidomimetics, anti-tumor, structure activity relationship

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