Abstract
Non-transferrin bound iron (NTBI) is known to facilitate reactive oxygen species generation which contributes to the development of tissue damage observed in various disorders like hemolytic anemia, hemochromatosis, diabetes mellitus or many forms of neonatal central nervous system damage. Here we are summarizing information about biochemical nature of NTBI and review methods developed for its detection in biological material. Ability to detect NTBI concentration is likely to become an essential tool when it comes to diagnosis of diseases characterized by excessive iron accumulation. In contrast to routinely used parameters such as transferrin saturation or ferritin concentration, NTBI is not affected by inflammatory responses which makes it a reliable indicator. Unfortunately, we are still lacking validated laboratory methods to detect NTBI in biological fluids.
Keywords: Non-transferrin bound iron, Bleomycin, Nitrilotriacetic acid, Desferrioxamine, Hemochromatosis, Clinical Implications, Bacterial siderophore desferrioxamine (DFO), Myelodysplastic syndromes (MDS), Thalassemia
Current Pharmaceutical Analysis
Title: Non-Transferrin Bound Iron - Determination in Biological Material and Clinical Implications
Volume: 7 Issue: 4
Author(s): Artur Slomka, Katarzyna Piotrowska, Marcin Koba and Ewa Zekanowska
Affiliation:
Keywords: Non-transferrin bound iron, Bleomycin, Nitrilotriacetic acid, Desferrioxamine, Hemochromatosis, Clinical Implications, Bacterial siderophore desferrioxamine (DFO), Myelodysplastic syndromes (MDS), Thalassemia
Abstract: Non-transferrin bound iron (NTBI) is known to facilitate reactive oxygen species generation which contributes to the development of tissue damage observed in various disorders like hemolytic anemia, hemochromatosis, diabetes mellitus or many forms of neonatal central nervous system damage. Here we are summarizing information about biochemical nature of NTBI and review methods developed for its detection in biological material. Ability to detect NTBI concentration is likely to become an essential tool when it comes to diagnosis of diseases characterized by excessive iron accumulation. In contrast to routinely used parameters such as transferrin saturation or ferritin concentration, NTBI is not affected by inflammatory responses which makes it a reliable indicator. Unfortunately, we are still lacking validated laboratory methods to detect NTBI in biological fluids.
Export Options
About this article
Cite this article as:
Slomka Artur, Piotrowska Katarzyna, Koba Marcin and Zekanowska Ewa, Non-Transferrin Bound Iron - Determination in Biological Material and Clinical Implications, Current Pharmaceutical Analysis 2011; 7 (4) . https://dx.doi.org/10.2174/157341211797458014
DOI https://dx.doi.org/10.2174/157341211797458014 |
Print ISSN 1573-4129 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-676X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Metabolic Syndrome and Non-Cardiac Vascular Diseases: An Update from Human Studies
Current Pharmaceutical Design Beneficial Effects of Statins on Endothelial Dysfunction and Vascular Stiffness
Current Vascular Pharmacology The Battle of the Sexes for Stroke Therapy: Female- Versus Male-Derived Stem Cells
CNS & Neurological Disorders - Drug Targets Niacin Status, NAD Distribution and ADP-Ribose Metabolism
Current Pharmaceutical Design Erythropoietin and Oxidative Stress
Current Neurovascular Research Therapeutic Agents for COVID-19: an Overview
Current Drug Therapy Cytokine Gene Variants as Predictors of Type 2 Diabetes Mellitus
Current Diabetes Reviews Metabolic Syndrome X is a Low-Grade Systemic Inflammatory Condition with its Origins in the Perinatal Period
Current Nutrition & Food Science Novel Approaches to the Pharmacotherapy of Obesity
Current Pharmaceutical Design Genomics and Natural Products: Role of Bioinformatics and Recent Patents
Recent Patents on Biotechnology Type 2 Diabetes and Obesity in Children and Adolescents: Experience from Studies in Taiwanese Population
Current Diabetes Reviews Bio-Antioxidants – A Chemical Base of Their Antioxidant Activity and Beneficial Effect on Human Health
Current Medicinal Chemistry Circulatory Estrogen Level Protects Against Breast Cancer in Obese Women
Recent Patents on Anti-Cancer Drug Discovery The Association of Fractalkine Receptor (T280M) Polymorphism in the Pathogenesis of Acute Coronary Syndrome in the Egyptian Population
Current Pharmaceutical Biotechnology Editorial (Hot Topic: Hypertension: A Serious Complication in Pregnancy)
Current Hypertension Reviews Recent Advancements in Diagnosis and Therapy of Liver Cirrhosis
Current Drug Targets Neuro-Psychiatric Alterations in Patients with Diabetic Foot Syndrome
CNS & Neurological Disorders - Drug Targets Preconception Counselling: A Five- Year Experience in a Teratology Information Service
Letters in Drug Design & Discovery Epidemiology and Costs of Hypertension-related Disorders
Current Pharmaceutical Design Role of NUCB2/nesfatin-1 in Glucose Control: Diverse Functions in Islets, Adipocytes and Brain
Current Pharmaceutical Design