Abstract
Dendrimers are polymeric compounds with highly branched structures and functionally tunable peripheral groups. Because of their low polydispersity, high degree of molecular uniformity, and precisely controlled structure, dendrimers are excellent models for demonstrating a variety of biological activities. With the attachment of metals ions and/or metals, metallodendrimers or dendrimer nanocomposites, respectively, provide diverse characters for a variety of applications. Functionalization with additional moieties, such as targeted peptides or chromophores, yields metallodendrimers that can find powerful applications and exceed the capabilities of nondendritic molecules or small molecule analogs. This review introduces the background of metallodendrimers and dendrimer nanocomposites. Biomedical applications of metallodendrimers and dendrimer nanocomposites will be discussed, including biomimetic catalysts, imaging contrast agents (especially for MRI imaging), or biomedical sensors and therapeutic agents.
Keywords: Metallodendrimers, dendrimer nanocomposites, biomimetic catalysts, contrast agents, biosensors, therapeutic agents, thermodynamic effects, epoxidation reaction, folate, magnetic resonance imaging (MRI)
Current Pharmaceutical Design
Title: Metallodendrimers and Dendrimer Nanocomposites
Volume: 17 Issue: 22
Author(s): Yi-Hsuan Tang, Adela Ya-Ting Huang, Po-Yu Chen, Hui-Ting Chen and Chai-Lin Kao
Affiliation:
Keywords: Metallodendrimers, dendrimer nanocomposites, biomimetic catalysts, contrast agents, biosensors, therapeutic agents, thermodynamic effects, epoxidation reaction, folate, magnetic resonance imaging (MRI)
Abstract: Dendrimers are polymeric compounds with highly branched structures and functionally tunable peripheral groups. Because of their low polydispersity, high degree of molecular uniformity, and precisely controlled structure, dendrimers are excellent models for demonstrating a variety of biological activities. With the attachment of metals ions and/or metals, metallodendrimers or dendrimer nanocomposites, respectively, provide diverse characters for a variety of applications. Functionalization with additional moieties, such as targeted peptides or chromophores, yields metallodendrimers that can find powerful applications and exceed the capabilities of nondendritic molecules or small molecule analogs. This review introduces the background of metallodendrimers and dendrimer nanocomposites. Biomedical applications of metallodendrimers and dendrimer nanocomposites will be discussed, including biomimetic catalysts, imaging contrast agents (especially for MRI imaging), or biomedical sensors and therapeutic agents.
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Cite this article as:
Tang Yi-Hsuan, Ya-Ting Huang Adela, Chen Po-Yu, Chen Hui-Ting and Kao Chai-Lin, Metallodendrimers and Dendrimer Nanocomposites, Current Pharmaceutical Design 2011; 17 (22) . https://dx.doi.org/10.2174/138161211797052367
DOI https://dx.doi.org/10.2174/138161211797052367 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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