Abstract
In recent years high throughput screening operations have become a critical application in functional and translational research. Although a seemingly unmanageable amount of data is generated by these high-throughput, largescale techniques, through careful planning, an effective Laboratory Information Management System (LIMS) can be developed and implemented in order to streamline all phases of a workflow. Just as important as data mining and analysis procedures at the end of complex processes is the tracking of individual steps of applications that generate such data. Ultimately, the use of a customized LIMS will enable users to extract meaningful results from large datasets while trusting the robustness of their assays. To illustrate the design of a custom LIMS, this practical example is provided to highlight the important aspects of the design of a LIMS to effectively modulate all aspects of an siRNA screening service. This system incorporates inventory management, control of workflow, data handling and interaction with investigators, statisticians and administrators. All these modules are regulated in a synchronous manner within the LIMS.
Keywords: Workflow, LIMS, high throughput screening, siRNA, cell line, human genome libraries, transfection reagents, Core Technician, threshold
Combinatorial Chemistry & High Throughput Screening
Title: Essential Attributes Identified in the Design of a Laboratory Information Management System for a High Throughput siRNA Screening Laboratory
Volume: 14 Issue: 9
Author(s): Geoffrey Grandjean, Ryan Graham and Geoffrey Bartholomeusz
Affiliation:
Keywords: Workflow, LIMS, high throughput screening, siRNA, cell line, human genome libraries, transfection reagents, Core Technician, threshold
Abstract: In recent years high throughput screening operations have become a critical application in functional and translational research. Although a seemingly unmanageable amount of data is generated by these high-throughput, largescale techniques, through careful planning, an effective Laboratory Information Management System (LIMS) can be developed and implemented in order to streamline all phases of a workflow. Just as important as data mining and analysis procedures at the end of complex processes is the tracking of individual steps of applications that generate such data. Ultimately, the use of a customized LIMS will enable users to extract meaningful results from large datasets while trusting the robustness of their assays. To illustrate the design of a custom LIMS, this practical example is provided to highlight the important aspects of the design of a LIMS to effectively modulate all aspects of an siRNA screening service. This system incorporates inventory management, control of workflow, data handling and interaction with investigators, statisticians and administrators. All these modules are regulated in a synchronous manner within the LIMS.
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Cite this article as:
Grandjean Geoffrey, Graham Ryan and Bartholomeusz Geoffrey, Essential Attributes Identified in the Design of a Laboratory Information Management System for a High Throughput siRNA Screening Laboratory, Combinatorial Chemistry & High Throughput Screening 2011; 14 (9) . https://dx.doi.org/10.2174/138620711796957152
DOI https://dx.doi.org/10.2174/138620711796957152 |
Print ISSN 1386-2073 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5402 |
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