Abstract
In type 1 diabetes, a failure in the regulation of either innate or acquired immunity may be the cause of autoimmune response. A cell population that may have a regulatory role of the immune response are the Natural Killer T (NKT) cells, which are a population expressing T lymphocyte antigen receptor (TCR), and a common marker for NK cells. A distinctive characteristic in NKT cells is their capacity to produce large amounts of immune-modulating cytokines. A decrease in the number and/or functional incapability of NKT cells is associated with progression of type 1 diabetes and with other self-immune diseases. However, the relevance of such findings is not completely understood. Limitations of the current studies include the existing methods to measure NKT activation and the lack of assessment of the expression of genes affected by NKT action. Nevertheless, the study of NKT cells may be a new clinical approach to detect individuals at risk for having type 1 diabetes. Additional studies are needed to evaluate the clinical value of this new predictive tool.
Keywords: Natural Killer T (NKT) cells, Type 1 diabetes, Class-I MHC-restricted T-cell associated molecule (CRTAM), T lymphocyte antigen receptor (TCR), Effector lymphocytes, Human Leukocytary Antigen (HLA), Tumor Necrosis Factor, Insulitis, Hyperglycemia, Immunoglobulin
Current Diabetes Reviews
Title: The Role of Natural Killer T (NKT) Cells in the Pathogenesis of Type 1 Diabetes
Volume: 7 Issue: 4
Author(s): Rita A. Gomez-Diaz, Mayra V. Aguilar, Elisa N. Meguro, Rocio H. Marquez, Eulalia G. Magana, M. Carmen Martinez-Garcia, Niels W. Rodarte, Carlos A. Aguilar-Salinas, Elsy Canche-Pool and Vianney Ortiz-Navarrete
Affiliation:
Keywords: Natural Killer T (NKT) cells, Type 1 diabetes, Class-I MHC-restricted T-cell associated molecule (CRTAM), T lymphocyte antigen receptor (TCR), Effector lymphocytes, Human Leukocytary Antigen (HLA), Tumor Necrosis Factor, Insulitis, Hyperglycemia, Immunoglobulin
Abstract: In type 1 diabetes, a failure in the regulation of either innate or acquired immunity may be the cause of autoimmune response. A cell population that may have a regulatory role of the immune response are the Natural Killer T (NKT) cells, which are a population expressing T lymphocyte antigen receptor (TCR), and a common marker for NK cells. A distinctive characteristic in NKT cells is their capacity to produce large amounts of immune-modulating cytokines. A decrease in the number and/or functional incapability of NKT cells is associated with progression of type 1 diabetes and with other self-immune diseases. However, the relevance of such findings is not completely understood. Limitations of the current studies include the existing methods to measure NKT activation and the lack of assessment of the expression of genes affected by NKT action. Nevertheless, the study of NKT cells may be a new clinical approach to detect individuals at risk for having type 1 diabetes. Additional studies are needed to evaluate the clinical value of this new predictive tool.
Export Options
About this article
Cite this article as:
A. Gomez-Diaz Rita, V. Aguilar Mayra, N. Meguro Elisa, H. Marquez Rocio, G. Magana Eulalia, Carmen Martinez-Garcia M., W. Rodarte Niels, A. Aguilar-Salinas Carlos, Canche-Pool Elsy and Ortiz-Navarrete Vianney, The Role of Natural Killer T (NKT) Cells in the Pathogenesis of Type 1 Diabetes, Current Diabetes Reviews 2011; 7 (4) . https://dx.doi.org/10.2174/157339911796397839
DOI https://dx.doi.org/10.2174/157339911796397839 |
Print ISSN 1573-3998 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6417 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Human Microdialysis
Current Pharmaceutical Biotechnology Arterial Thickness and Immunometabolism: The Mediating role of Chronic Exercise
Current Cardiology Reviews Aqueous Extract of Anabasis aretioides Ameliorates Streptozotocininduced Diabetes Mellitus in Rats
The Natural Products Journal Alternative Medicine as a Treatment Option for COVID-19
Current Traditional Medicine Endless Pursuit: Evolution of Insulin Administration
Current Pharmaceutical Biotechnology Prevention of Vascular Complications in Diabetes Mellitus Patients: Focus on the Arterial Wall
Current Vascular Pharmacology Pharmacological Regulation of Dyslipoproteinaemia in Insulin Resistant States
Current Vascular Pharmacology Melatonin and Oxidative Stress in the Diabetic State: Clinical Implications and Potential Therapeutic Applications
Current Medicinal Chemistry Neuroprotective Effects of Exercise Treatments After Injury: The Dual Role of Neurotrophic Factors
Current Neuropharmacology Transition of Growth Hormone Treatment: Adolescence to Adulthood
Current Pediatric Reviews Energetic Metabolic Roles in Pulmonary Arterial Hypertension and Right Ventricular Remodeling
Current Pharmaceutical Design The Role of Asymmetric Dimethylarginine (ADMA) in Endothelial Dysfunction and Cardiovascular Disease
Current Cardiology Reviews Turnover Studies on Cardiac Natriuretic Peptides: Methodological,Pathophysiological and Therapeutical Considerations.
Current Drug Metabolism Effectiveness of Long-Term Macrolide Therapy in Cryptogenic Organising Pneumonia
Current Respiratory Medicine Reviews mTOR: A Novel Therapeutic Target for Diseases of Multiple Systems
Current Drug Targets The Potential Role of Sirtuins Regarding the Effects of Exercise on Aging- Related Diseases
Current Aging Science Measurement of Serum Monoamine Oxidase in Lichen Planus Patients and Its Clinical Significance
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Chemokine Like Receptor-1 (CMKLR-1) Receptor: A Potential Therapeutic Target in Management of Chemerin Induced Type 2 Diabetes Mellitus and Cancer
Current Pharmaceutical Design Sympathetic Overactivity in Patients with Chronic Renal Failure - The Culprit of Increased Cardiovascular Mortality?
Current Hypertension Reviews Structure-Activity Relationships of Flavonoids
Current Organic Chemistry