Abstract
An efficient solution-phase parallel procedure to perform the structural diversification of some formyl-nitrogen heterocycles (A) using the reusable TBD supported base is described. The library synthesis is based in a consecutive Alkylation-Knoevenagel functionalisation that uses alkyl halides (B), Michael acceptors (C) and activated methylene compounds (D) as diversity elements.
Keywords: Aza-Michael, Knoevenagel, polymer supported superbases, solution phase synthesis, TBD-Assisted, structural diversification, TBD, Alkylation, alkyl halides, methylene compounds, synthetic organic chemistry, high atom economy
Combinatorial Chemistry & High Throughput Screening
Title: Supported TBD-Assisted Solution Phase Diversification of Formyl-Aza-Heterocycles Through Alkylation-Knoevenagel One Pot Sequences
Volume: 14 Issue: 7
Author(s): Abdelaziz El Maatougui, Abel Crespo, Artur M.S. Silva and Alberto Coelho
Affiliation:
Keywords: Aza-Michael, Knoevenagel, polymer supported superbases, solution phase synthesis, TBD-Assisted, structural diversification, TBD, Alkylation, alkyl halides, methylene compounds, synthetic organic chemistry, high atom economy
Abstract: An efficient solution-phase parallel procedure to perform the structural diversification of some formyl-nitrogen heterocycles (A) using the reusable TBD supported base is described. The library synthesis is based in a consecutive Alkylation-Knoevenagel functionalisation that uses alkyl halides (B), Michael acceptors (C) and activated methylene compounds (D) as diversity elements.
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Cite this article as:
El Maatougui Abdelaziz, Crespo Abel, M.S. Silva Artur and Coelho Alberto, Supported TBD-Assisted Solution Phase Diversification of Formyl-Aza-Heterocycles Through Alkylation-Knoevenagel One Pot Sequences, Combinatorial Chemistry & High Throughput Screening 2011; 14 (7) . https://dx.doi.org/10.2174/138620711796367229
DOI https://dx.doi.org/10.2174/138620711796367229 |
Print ISSN 1386-2073 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5402 |
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