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Current Organic Chemistry

Editor-in-Chief

ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Isosteviol as a Starting Material in Organic Synthesis

Author(s): Nico Moons, Wim De Borggraeve and Wim Dehaen

Volume 15, Issue 15, 2011

Page: [2731 - 2741] Pages: 11

DOI: 10.2174/138527211796367372

Price: $65

Abstract

In recent years the diterpene isosteviol, obtained via acid catalyzed rearrangement of stevioside, has gained growing interest by scientists. Its structural features and easy accessibility make isosteviol a useful starting material in organic synthesis. In this review, we group all existing modifications to the isosteviol moiety, ranging from biological transformation to rearrangements of the terpene skeleton. We will also discuss the known macrocycles based on isosteviol

Keywords: Derivatisation, diterpene, hydroxylation, isosteviol, rearrangements, stevioside, supramolecular, ringtransformation, aglycones, diterpene derivatives, steviol, stevia glycosides, stereoselectivities

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