Abstract
High dietary intake of fruits and vegetables is consistently associated with a reduced risk of common human cancers. The specific mechanisms of action of most phytochemicals in cancer prevention are not yet clear but appear to be varied. One class of compounds currently under investigation is flavonoids, a large group of molecules with similar structure. Although their bioavailability is discussed, numerous in vitro and animal model data suggest that flavonoids modulate important cellular and molecular mechanisms related to carcinogenesis, a multistep process involving the transformation, survival, proliferation, invasion, angiogenesis, and metastasis of the tumor cells. Epidemiological studies confirmed that, among many flavonoids, apigenin, epigallocatechin gallate, delphinidin and genistein appear to be beneficial compounds in various stages of carcinogenesis. Therefore, according to in vitro and in vivo studies, this review attempts to increase our understanding about the preventive and therapeutic effects of these compounds to facilitate extrapolation of results from animal studies to human situations.
Keywords: Flavonoids, apigenin, EGCG, delphinidin, genistein, angiogenesis, carcinogenesis, tumor initiation, tumor progression, metastasis, tumor microenvironment
Cardiovascular & Hematological Agents in Medicinal Chemistry
Title: Anticancer Properties of Flavonoids: Roles in Various Stages of Carcinogenesis
Volume: 9 Issue: 2
Author(s): Nicolas Clere, Sebastien Faure, Maria Carmen Martinez and Ramaroson Andriantsitohaina
Affiliation:
Keywords: Flavonoids, apigenin, EGCG, delphinidin, genistein, angiogenesis, carcinogenesis, tumor initiation, tumor progression, metastasis, tumor microenvironment
Abstract: High dietary intake of fruits and vegetables is consistently associated with a reduced risk of common human cancers. The specific mechanisms of action of most phytochemicals in cancer prevention are not yet clear but appear to be varied. One class of compounds currently under investigation is flavonoids, a large group of molecules with similar structure. Although their bioavailability is discussed, numerous in vitro and animal model data suggest that flavonoids modulate important cellular and molecular mechanisms related to carcinogenesis, a multistep process involving the transformation, survival, proliferation, invasion, angiogenesis, and metastasis of the tumor cells. Epidemiological studies confirmed that, among many flavonoids, apigenin, epigallocatechin gallate, delphinidin and genistein appear to be beneficial compounds in various stages of carcinogenesis. Therefore, according to in vitro and in vivo studies, this review attempts to increase our understanding about the preventive and therapeutic effects of these compounds to facilitate extrapolation of results from animal studies to human situations.
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Clere Nicolas, Faure Sebastien, Carmen Martinez Maria and Andriantsitohaina Ramaroson, Anticancer Properties of Flavonoids: Roles in Various Stages of Carcinogenesis, Cardiovascular & Hematological Agents in Medicinal Chemistry 2011; 9 (2) . https://dx.doi.org/10.2174/187152511796196498
DOI https://dx.doi.org/10.2174/187152511796196498 |
Print ISSN 1871-5257 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6182 |
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