Abstract
Protein kinases are key regulators of cell function that constitute one of the largest and most functionally diverse gene families, and knowledge of their three-dimensional structure could be of great help in the rational design of specific ligands. However, only about one quarter of human protein kinase structures has been experimentally defined; thus, kinase homology modeling techniques have been widely diffused. In this review, the most recent kinase homology models are reported, together with the most recent approaches and the main validation methods.
Keywords: Kinase, homology modeling, virtual screening, docking, kinase inhibitors
Current Medicinal Chemistry
Title: Protein Kinase Homology Models: Recent Developments and Results
Volume: 18 Issue: 19
Author(s): T. Tuccinardi and Adriano Martinelli
Affiliation:
Keywords: Kinase, homology modeling, virtual screening, docking, kinase inhibitors
Abstract: Protein kinases are key regulators of cell function that constitute one of the largest and most functionally diverse gene families, and knowledge of their three-dimensional structure could be of great help in the rational design of specific ligands. However, only about one quarter of human protein kinase structures has been experimentally defined; thus, kinase homology modeling techniques have been widely diffused. In this review, the most recent kinase homology models are reported, together with the most recent approaches and the main validation methods.
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Cite this article as:
Tuccinardi T. and Martinelli Adriano, Protein Kinase Homology Models: Recent Developments and Results, Current Medicinal Chemistry 2011; 18 (19) . https://dx.doi.org/10.2174/092986711796150441
DOI https://dx.doi.org/10.2174/092986711796150441 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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