PCL/PEG Copolymeric Nanoparticles: Potential Nanoplatforms for Anticancer Agent Delivery

MaLing      Gou; XiaWei      Wei; Ke      Men; BiLan      Wang; Feng      Luo; Xia      Zhao; YuQuan      Wei; ZhiYong      Qian

Abstract

Nanotechnology provides researchers with new tools for cancer treatment. Biodegradable polymeric nanoparticles, as an advanced drug delivery system, have promising applications in cancer treatment. Poly(- caprolactone)/poly(ethylene glycol) (PCL/PEG) copolymers are biodegradable and amphiphilic, and show potential application in drug delivery. In recent years, PCL/PEG copolymeric nanoparticles, as a potential nanoplatform for anticancer agent delivery, received increasing attention. This paper reviews PCL/PEG copolymer nanoparticles for anticancer agent delivery, including overcoming water insolubility of hydrophobic drug, targeting chemotherapeutic drug to tumor, and delivering genes, vaccines, and diagnostic agents.

Keywords: Biodegradable polymer, cancer, diagnostic agent, drug delivery system, gene delivery, nanoparticle, poly(-caprolactone)/poly(ethylene glycol) (PCL/PEG) copolymers, vaccine, nano-precipitation method, chemotherapy