Abstract
The major problem in oral drug formulations is low and erratic bioavailability, which mainly results from poor aqueous solubility. This may lead to high inter- and intra subject variability, lack of dose proportionality and therapeutic failure. The improvement of bioavailability of drugs with such properties presents one of the greatest challenges in drug formulations. Oral lipid based formulations are attracting considerable attention due to their capacity to increase the solubility, facilitating gastrointestinal absorption and reduce or eliminate the effect of food on the absorption of poorly water soluble, lipophilic drug and thus increasing the bioavailability. The present review outlines the recent findings on selfemulsifying drug delivery system (SEDDS), self-micro/nanoemulsifying drug delivery system (SMEDDS/SNEDDS) and evaluation of these formulations published over the past decade. The application of lipid based formulations as a promising system for the oral delivery of many therapeutic agents including traditional medicine (TM) has also been examined in the current review.
Keywords: Self-Micro/Nanoemulsifying drug delivery system (SMEDDS/SNEDDS), Solubility, Bioavailability, Oral absorption, Surfactant, Co-surfactant, LBDDS, Cyclosporin A, specific absorption, Digestion of lipids
Current Drug Delivery
Title: Oral Lipid Based Drug Delivery System (LBDDS): Formulation, Characterization and Application: A Review
Volume: 8 Issue: 4
Author(s): Md. Akhlaquer Rahman, Ranjit Harwansh, Mohd. Aamir Mirza, Sarfaraj Hussain and Arshad Hussain
Affiliation:
Keywords: Self-Micro/Nanoemulsifying drug delivery system (SMEDDS/SNEDDS), Solubility, Bioavailability, Oral absorption, Surfactant, Co-surfactant, LBDDS, Cyclosporin A, specific absorption, Digestion of lipids
Abstract: The major problem in oral drug formulations is low and erratic bioavailability, which mainly results from poor aqueous solubility. This may lead to high inter- and intra subject variability, lack of dose proportionality and therapeutic failure. The improvement of bioavailability of drugs with such properties presents one of the greatest challenges in drug formulations. Oral lipid based formulations are attracting considerable attention due to their capacity to increase the solubility, facilitating gastrointestinal absorption and reduce or eliminate the effect of food on the absorption of poorly water soluble, lipophilic drug and thus increasing the bioavailability. The present review outlines the recent findings on selfemulsifying drug delivery system (SEDDS), self-micro/nanoemulsifying drug delivery system (SMEDDS/SNEDDS) and evaluation of these formulations published over the past decade. The application of lipid based formulations as a promising system for the oral delivery of many therapeutic agents including traditional medicine (TM) has also been examined in the current review.
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Cite this article as:
Akhlaquer Rahman Md., Harwansh Ranjit, Aamir Mirza Mohd., Hussain Sarfaraj and Hussain Arshad, Oral Lipid Based Drug Delivery System (LBDDS): Formulation, Characterization and Application: A Review, Current Drug Delivery 2011; 8 (4) . https://dx.doi.org/10.2174/156720111795767906
DOI https://dx.doi.org/10.2174/156720111795767906 |
Print ISSN 1567-2018 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5704 |
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