High Dose Zolpidem Induced Fetal Neural Tube Defects

Title: High Dose Zolpidem Induced Fetal Neural Tube Defects

Volume: 6 Issue: 2

Author(s): Avinash Sharma, Neha Sayeed, Christoday R.J. Khess and Sayeed Akhtar

Affiliation:

Keywords: Neural tube defects, zolpidem, high dose, teratogenicity, meningo-myelocele

Abstract: Use of zolpidem, a short-acting imidazopyridine hypnotic, has not been associated with teratogenic effects in usual clinical doses. We report a case of fetal neural tube defects occurring in a female dependent on zolpidem and consuming high doses in the first trimester of pregnancy. Possible mechanisms by which high dose zolpidem may lead to teratogenicity are discussed. Clinicians are advised to be aware of the risks of high-dose zolpidem abuse in early pregnancy.

Cite this article as:

Sharma Avinash, Sayeed Neha, R.J. Khess Christoday and Akhtar Sayeed, High Dose Zolpidem Induced Fetal Neural Tube Defects, Current Drug Safety 2011; 6 (2) . https://dx.doi.org/10.2174/157488611795684695