Abstract
New nanomaterials have been extensively explored in recent years for drug delivery applications to address problems associated with the conventional drug therapies such as limited drug solubility, poor biodistribution, lack of selectivity and unfavourable pharmacokinetics. Among them, carbon nanotubes (CNTs) have attracted great attention due to their unique physicochemical architecture and properties. This comprehensive review summarizes the recent advances regarding the use of CNTs for drug delivery. This review includes general information about CNT structures and properties, methods for their dispersion in aqueous solution and basic concepts for CNTs functionalization relevant for their applications in biological systems and delivery of therapeutics. Some toxicological and biocompatibility issues related to the use of CNTs as pharmaceutical excipients are discussed. Last, recent progress on development of CNT drug delivery systems with a specific emphasis on gene delivery was reviewed.
Keywords: Carbon nanotubes, functionalization of carbon nanotubes, drug delivery, gene delivery, single walled carbon nanotubes, multi-walled carbon nanotubes, solubility of carbon nanotubes, carbon nanotubes composites, click chemistry, toxicity of carbon nanotubes, Genotoxicity and Mutagenicity of carbon nanotubes, cancer drugs delivery, RNA delivery, DNA delivery
Current Nanoscience
Title: Carbon Nanotubes as an Advanced Drug and Gene Delivery Nanosystem
Volume: 7 Issue: 3
Author(s): Jafar Ezzati Nazhad Dolatabadi, Yadollah Omidi and Dusan Losic
Affiliation:
Keywords: Carbon nanotubes, functionalization of carbon nanotubes, drug delivery, gene delivery, single walled carbon nanotubes, multi-walled carbon nanotubes, solubility of carbon nanotubes, carbon nanotubes composites, click chemistry, toxicity of carbon nanotubes, Genotoxicity and Mutagenicity of carbon nanotubes, cancer drugs delivery, RNA delivery, DNA delivery
Abstract: New nanomaterials have been extensively explored in recent years for drug delivery applications to address problems associated with the conventional drug therapies such as limited drug solubility, poor biodistribution, lack of selectivity and unfavourable pharmacokinetics. Among them, carbon nanotubes (CNTs) have attracted great attention due to their unique physicochemical architecture and properties. This comprehensive review summarizes the recent advances regarding the use of CNTs for drug delivery. This review includes general information about CNT structures and properties, methods for their dispersion in aqueous solution and basic concepts for CNTs functionalization relevant for their applications in biological systems and delivery of therapeutics. Some toxicological and biocompatibility issues related to the use of CNTs as pharmaceutical excipients are discussed. Last, recent progress on development of CNT drug delivery systems with a specific emphasis on gene delivery was reviewed.
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Cite this article as:
Ezzati Nazhad Dolatabadi Jafar, Omidi Yadollah and Losic Dusan, Carbon Nanotubes as an Advanced Drug and Gene Delivery Nanosystem, Current Nanoscience 2011; 7 (3) . https://dx.doi.org/10.2174/157341311795542444
DOI https://dx.doi.org/10.2174/157341311795542444 |
Print ISSN 1573-4137 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6786 |
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