Abstract
Biologically active peptides and proteins have a great potential to act as targeted drug therapies in the treatment of a variety of diseases, including cancer. However, their use in vivo is limited by their low stability and cell permeability. Thus, it is necessary to develop efficient and safe peptide/protein delivery systems that can overcome these problems and increase a therapy's bioavailability. The search for promising vectors has led to the use of compounds called cell-penetrating peptides or protein transduction domains. The cellpenetrating peptides, as effective transporter, are utilized to enhance uptake of various biologically active peptide/protein cargos upon fusion or attachment to its sequences. Cell-penetrating peptides have been the subject of investigation of many researchers, however this review only focuses on the arginine-rich and amphipathic carriers and their potential therapeutic use.
Keywords: Drug delivery, protein transduction, TAT, amphipathic peptides, CPP, CTP, cell, liposome, electroporation, plasma
Current Medicinal Chemistry
Title: The Delivery of Biologically Active (Therapeutic) Peptides and Proteins into Cells
Volume: 18 Issue: 9
Author(s): M. Grdisa
Affiliation:
Keywords: Drug delivery, protein transduction, TAT, amphipathic peptides, CPP, CTP, cell, liposome, electroporation, plasma
Abstract: Biologically active peptides and proteins have a great potential to act as targeted drug therapies in the treatment of a variety of diseases, including cancer. However, their use in vivo is limited by their low stability and cell permeability. Thus, it is necessary to develop efficient and safe peptide/protein delivery systems that can overcome these problems and increase a therapy's bioavailability. The search for promising vectors has led to the use of compounds called cell-penetrating peptides or protein transduction domains. The cellpenetrating peptides, as effective transporter, are utilized to enhance uptake of various biologically active peptide/protein cargos upon fusion or attachment to its sequences. Cell-penetrating peptides have been the subject of investigation of many researchers, however this review only focuses on the arginine-rich and amphipathic carriers and their potential therapeutic use.
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Cite this article as:
Grdisa M., The Delivery of Biologically Active (Therapeutic) Peptides and Proteins into Cells, Current Medicinal Chemistry 2011; 18 (9) . https://dx.doi.org/10.2174/092986711795029591
DOI https://dx.doi.org/10.2174/092986711795029591 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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