Abstract
Intrahepatic cholestasis of pregnancy is the most common liver disease occurring in the second half of pregnancy, characterized by pruritus and elevated serum bile acids often coupled to abnormal liver tests. Maternal prognosis is favourable with a complete symptom resolution after delivery, while preterm deliveries, fetal respiratory distress and stillbirths may occur. The goal of the pharmacological treatment of the disease is to improve maternal symptoms and biochemical alterations and, most importantly, to reduce fetal adverse events. The present manuscript will review the current knowledge on the pharmacological treatment of intrahepatic cholestasis of pregnancy.
Keywords: Bile acids, cholestasis, pregnancy, pruritus, treatment, ursodeoxycholic acid, S-adenosyl-methionine, glucocorticoid therapy, Elevated Liver, Low Platelets, Haemolysis
Current Clinical Pharmacology
Title: The Pharmacological Management of Intrahepatic Cholestasis of Pregnancy
Volume: 6 Issue: 1
Author(s): Francesco Azzaroli, Laura Turco, Andrea Lisotti, Claudio Calvanese and Giuseppe Mazzella
Affiliation:
Keywords: Bile acids, cholestasis, pregnancy, pruritus, treatment, ursodeoxycholic acid, S-adenosyl-methionine, glucocorticoid therapy, Elevated Liver, Low Platelets, Haemolysis
Abstract: Intrahepatic cholestasis of pregnancy is the most common liver disease occurring in the second half of pregnancy, characterized by pruritus and elevated serum bile acids often coupled to abnormal liver tests. Maternal prognosis is favourable with a complete symptom resolution after delivery, while preterm deliveries, fetal respiratory distress and stillbirths may occur. The goal of the pharmacological treatment of the disease is to improve maternal symptoms and biochemical alterations and, most importantly, to reduce fetal adverse events. The present manuscript will review the current knowledge on the pharmacological treatment of intrahepatic cholestasis of pregnancy.
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Cite this article as:
Azzaroli Francesco, Turco Laura, Lisotti Andrea, Calvanese Claudio and Mazzella Giuseppe, The Pharmacological Management of Intrahepatic Cholestasis of Pregnancy, Current Clinical Pharmacology 2011; 6 (1) . https://dx.doi.org/10.2174/157488411794941313
DOI https://dx.doi.org/10.2174/157488411794941313 |
Print ISSN 1574-8847 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3938 |
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