Abstract
Pain and inflammation are considered strongly associated. The greater pain behavior was demonstrated in animals with greater amount of inflammation. Tissue or nerve injury results in the release of various inflammatory mediators such as prostaglandins, bradykinin, proinflammatory cytokines, chemokines, histamine, serotonin and nerve growth factors from the site of injury. These inflammatory mediators play a critical role in both integrating the inflammatory response and mediating pain hypersensitivity. This review highlights the role of prostaglandins and proinflammatory cytokines in the pain sensitization and its underlying mechanisms, emphasizing the evidence that these molecules are potential targets to develop novel drugs and therapies for the treatment of both inflammation and pain in clinic.
Keywords: Inflammation, pain, prostaglandins, proinflammatory cytokines, hyperalgesia, bradykinin, COX, Tetrodotoxin (TTX) resistant, Tumor- necrosis factor- alpha (TNF- ), GlucocortiCoids
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Title: Pain Alleviation in Anti-Inflammatory and Anti-Allergic Conditions
Volume: 10 Issue: 1
Author(s): Ceng Luo, Rou-Gang Xie and San-Jue Hu
Affiliation:
Keywords: Inflammation, pain, prostaglandins, proinflammatory cytokines, hyperalgesia, bradykinin, COX, Tetrodotoxin (TTX) resistant, Tumor- necrosis factor- alpha (TNF- ), GlucocortiCoids
Abstract: Pain and inflammation are considered strongly associated. The greater pain behavior was demonstrated in animals with greater amount of inflammation. Tissue or nerve injury results in the release of various inflammatory mediators such as prostaglandins, bradykinin, proinflammatory cytokines, chemokines, histamine, serotonin and nerve growth factors from the site of injury. These inflammatory mediators play a critical role in both integrating the inflammatory response and mediating pain hypersensitivity. This review highlights the role of prostaglandins and proinflammatory cytokines in the pain sensitization and its underlying mechanisms, emphasizing the evidence that these molecules are potential targets to develop novel drugs and therapies for the treatment of both inflammation and pain in clinic.
Export Options
About this article
Cite this article as:
Luo Ceng, Xie Rou-Gang and Hu San-Jue, Pain Alleviation in Anti-Inflammatory and Anti-Allergic Conditions, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2011; 10 (1) . https://dx.doi.org/10.2174/187152311795325497
DOI https://dx.doi.org/10.2174/187152311795325497 |
Print ISSN 1871-5230 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-614X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Protein Phosphatase Inhibition: Structure Based Design. Towards New Therapeutic Agents
Current Pharmaceutical Design Subclinical Hypothyroidism and Heart Failure Risk in Older People
Endocrine, Metabolic & Immune Disorders - Drug Targets Domperidone and Long QT Syndrome
Current Drug Safety Effect of Rehabilitative Exercise Training on Peripheral Muscle Remodelling in Patients with COPD: Targeting Beyond the Lungs
Current Drug Targets Opportunities for Pharmacotherapy at the Intersection of Metabolic Syndrome and Hemostasis
Current Pharmaceutical Biotechnology Molecular Diversity of Hydroxamic Acids: Part II. Potential Therapeutic Applications
Mini-Reviews in Medicinal Chemistry Non-ACE Pathway-induced Angiotensin II Production
Current Pharmaceutical Design Molecular Mechanisms in Rheumatic Diseases: Rationale for Novel Drug Development – Introduction
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Review and Research on Feature Selection Methods from NMR Data in Biological Fluids. Presentation of an Original Ensemble Method Applied to Atherosclerosis Field
Current Drug Metabolism Oxidative Stress-Induced Ischemic Heart Disease: Protection by Antioxidants
Current Medicinal Chemistry Inflammatory Mediators and the Failing Heart: A Translational Approach
Current Molecular Medicine Validation of Acute Liver Injury Cases in a Population-Based Cohort Study of Oral Antimicrobial Users
Current Drug Safety The Role and Predictive Value of Cytokines in Atherosclerosis and Coronary Artery Disease
Current Medicinal Chemistry The L-Type Ca2+ Channel as a Therapeutic Target in Heart Disease
Current Medicinal Chemistry Systemic Adverse Drug Reactions Secondary to Anti-VEGF Intravitreal Injection in Patients with Neovascular Age-Related Macular Degeneration
Current Vascular Pharmacology Application of Pharmacogenomics to Dietary Cancer Chemoprevention
Current Pharmacogenomics APO2L/TRAIL: New Insights in the Treatment of Autoimmune Disorders
Recent Patents on Inflammation & Allergy Drug Discovery Isothiocyanates as Cancer Chemopreventive Agents: Their Biological Activities and Metabolism in Rodents and Humans
Current Drug Metabolism Microvascular Obstruction After Primary Percutaneous Coronary Intervention: Pathogenesis, Diagnosis and Prognostic Significance
Current Vascular Pharmacology Hypertriglyceridemia - Common Causes, Prevention and treatment Strategies
Current Cardiology Reviews