Abstract
Approximately, 63% of marketed drugs derive from natural products or their semi synthetic derivatives. Compounds from living organisms often exert a biological activity, triggering several targets, which may be useful for the improvement of novel pharmaceuticals. These natural products can be extracted from plants, marine organisms, or microorganism fermentation broths. In the vast array of bioactive secondary metabolites known up to now, anthraquinones are among the most investigated natural products, in particular for what concerns their mechanism of action. This review focuses on the analytical aspects of anthraquinones, from their separation to recent and new highthroughputs techniques for the simultaneous determination of these analytes in biological matrices that can greatly contribute to sharply depict the targets of these secondary metabolites as well as on an updated survey of their biological activities.
Keywords: Analytical techniques, natural bioactive compounds, anthraquinones, food and health, Biological Targets, pharmaceuticals, De Materia Medica, Rhamnus, emodine, physcione, aloe-emodine, Chrysophanol, Physcione, ultrasonication assay, high-throughput combination, chromatography, capillary electrophoresis, Reusable cartridges, HPLC-SPENMR-MS-FT-IR, Anthracenedione (anthraquinone), methoxyanthraquinone
Current Drug Targets
Title: Anthraquinones: Analytical Techniques as a Novel Tool to Investigate on the Triggering of Biological Targets
Volume: 12 Issue: 3
Author(s): Marcello Locatelli
Affiliation:
Keywords: Analytical techniques, natural bioactive compounds, anthraquinones, food and health, Biological Targets, pharmaceuticals, De Materia Medica, Rhamnus, emodine, physcione, aloe-emodine, Chrysophanol, Physcione, ultrasonication assay, high-throughput combination, chromatography, capillary electrophoresis, Reusable cartridges, HPLC-SPENMR-MS-FT-IR, Anthracenedione (anthraquinone), methoxyanthraquinone
Abstract: Approximately, 63% of marketed drugs derive from natural products or their semi synthetic derivatives. Compounds from living organisms often exert a biological activity, triggering several targets, which may be useful for the improvement of novel pharmaceuticals. These natural products can be extracted from plants, marine organisms, or microorganism fermentation broths. In the vast array of bioactive secondary metabolites known up to now, anthraquinones are among the most investigated natural products, in particular for what concerns their mechanism of action. This review focuses on the analytical aspects of anthraquinones, from their separation to recent and new highthroughputs techniques for the simultaneous determination of these analytes in biological matrices that can greatly contribute to sharply depict the targets of these secondary metabolites as well as on an updated survey of their biological activities.
Export Options
About this article
Cite this article as:
Locatelli Marcello, Anthraquinones: Analytical Techniques as a Novel Tool to Investigate on the Triggering of Biological Targets, Current Drug Targets 2011; 12 (3) . https://dx.doi.org/10.2174/138945011794815338
DOI https://dx.doi.org/10.2174/138945011794815338 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
Call for Papers in Thematic Issues
New drug therapy for eye diseases
Eyesight is one of the most critical senses, accounting for over 80% of our perceptions. Our quality of life might be significantly affected by eye disease, including glaucoma, diabetic retinopathy, dry eye, etc. Although the development of microinvasive ocular surgery reduces surgical complications and improves overall outcomes, medication therapy is ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Molecular Fundamentals and Rationale for Immunotherapy in Metastatic Melanoma Treatment
Clinical Cancer Drugs Vascularization of Biomaterials for Bone Tissue Engineering: Current Approaches and Major Challenges
Current Angiogenesis (Discontinued) Intraoperative Magnetic Resonance Imaging
Current Medical Imaging Roles of TRAF6 in Central Nervous System
Current Neuropharmacology CD44 and EpCAM: Cancer-Initiating Cell Markers
Current Molecular Medicine Critical Steps in Tissue Processing in Histopathology
Recent Patents on DNA & Gene Sequences The Potential Therapeutic Value of Renin-Angiotensin System Inhibitors in the Treatment of Colorectal Cancer
Current Pharmaceutical Design A Brief Evaluation of Tumor Imaging in Mice with 99mTc-glucarate Including a Comparison with 18F-FDG
Current Radiopharmaceuticals Gemini Surfactant Based Carriers in Gene and Drug Delivery
Current Medicinal Chemistry Tumor Escape from Immune Response: Mechanisms and Targets of Activity
Current Drug Targets PI-3 Kinase-PTEN Signaling Node: An Intercept Point for the Control of Angiogenesis
Current Pharmaceutical Design A Feature-Free 30-Disease Pathological Brain Detection System by Linear Regression Classifier
CNS & Neurological Disorders - Drug Targets 1,2,4-Triazine Analogs as Novel Class of Therapeutic Agents
Mini-Reviews in Medicinal Chemistry Signal Transduction Pathways of Taxanes-Induced Apoptosis
Current Medicinal Chemistry - Anti-Cancer Agents Gamma Linolenic Acid: An Antiinflammatory Omega-6 Fatty Acid
Current Pharmaceutical Biotechnology On the Nature of the Tumor-Initiating Cell
Current Stem Cell Research & Therapy Combination of Salinomycin and AZD3463 Reveals Synergistic Effect on Reducing the Viability of T98G Glioblastoma Cells
Anti-Cancer Agents in Medicinal Chemistry Pioglitazone Prevents Smoking Carcinogen-Induced Lung Tumor Development in Mice
Current Cancer Drug Targets Role of Inflammatory Mediators in Angiogenesis
Current Drug Targets - Inflammation & Allergy Inhibitors for Metastasis Development
Recent Patents on Anti-Cancer Drug Discovery