Abstract
TRPV1 and TRPA1 have traditionally been considered to function independently from each other as homomers, but their extensive co-expression in sensory neurons and recent evidence suggest that these channels can functionally interact and may form a complex as part of their normal function. Although TRPA1 and TRPV1 do not absolutely require interaction to maintain function in expression systems or even sensory neurons, their heteromerization may still result in dramatic effects on channel biophysical properties, pharmacology, signaling, regulation, and ultimately function. Understanding the regulation and functional significance of TRPA1-TRPV1 interaction is of tremendous clinical importance since first, both channels are the potential molecular targets for numerous therapeutic drugs; and second, TRPA1- TRPV1 co-expression is far more specific for nociceptive sensory neurons than expression patterns of TRPA1 or TRPV1 considered separately.
Keywords: TRPV1, TRPA1, nociceptors, TRPV1 Interactions, nociception, TRP, TRP-like channels, TRPL, inflammatory mediators, trigeminal ganglia, nodose-petrosal ganglion complex, TRPV1-positive neurons, nerve growth factor, co-immunoprecipitation, TIRF, cannabinoid AM1241, capsazepine, I-RTX, desensitization, calcineurin, PIP2, bradykinin, neurogenic inflammation, BK-induced hyperalgesia, BK responses, FRET interaction, cannabinoid-gated currents, AM630, channel blocker, TRPA1-TRPV1 complex, nociceptive transmission
Current Pharmaceutical Biotechnology
Title: Regulation of Nociceptive Transmission at the Periphery Via TRPA1-TRPV1 Interactions
Volume: 12 Issue: 1
Author(s): Armen N. Akopian
Affiliation:
Keywords: TRPV1, TRPA1, nociceptors, TRPV1 Interactions, nociception, TRP, TRP-like channels, TRPL, inflammatory mediators, trigeminal ganglia, nodose-petrosal ganglion complex, TRPV1-positive neurons, nerve growth factor, co-immunoprecipitation, TIRF, cannabinoid AM1241, capsazepine, I-RTX, desensitization, calcineurin, PIP2, bradykinin, neurogenic inflammation, BK-induced hyperalgesia, BK responses, FRET interaction, cannabinoid-gated currents, AM630, channel blocker, TRPA1-TRPV1 complex, nociceptive transmission
Abstract: TRPV1 and TRPA1 have traditionally been considered to function independently from each other as homomers, but their extensive co-expression in sensory neurons and recent evidence suggest that these channels can functionally interact and may form a complex as part of their normal function. Although TRPA1 and TRPV1 do not absolutely require interaction to maintain function in expression systems or even sensory neurons, their heteromerization may still result in dramatic effects on channel biophysical properties, pharmacology, signaling, regulation, and ultimately function. Understanding the regulation and functional significance of TRPA1-TRPV1 interaction is of tremendous clinical importance since first, both channels are the potential molecular targets for numerous therapeutic drugs; and second, TRPA1- TRPV1 co-expression is far more specific for nociceptive sensory neurons than expression patterns of TRPA1 or TRPV1 considered separately.
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Cite this article as:
N. Akopian Armen, Regulation of Nociceptive Transmission at the Periphery Via TRPA1-TRPV1 Interactions, Current Pharmaceutical Biotechnology 2011; 12 (1) . https://dx.doi.org/10.2174/138920111793937952
DOI https://dx.doi.org/10.2174/138920111793937952 |
Print ISSN 1389-2010 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4316 |
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