Abstract
Type 2 diabetes mellitus is a growing health problem across the world. Thiazolidinediones, a new class of oral antidiabetic agents, appear to be ideally suited for the treatment of this disease. The examination of the clinical efficacy of different thiazolidinediones has been extensive. This review summarizes the current state of the cut concerning the clinical use of different thiazolidinediones, starting from the first synthetic thiazolidinediones to the recently developed glitazones. A main focus of this review is the description of the chemistry of these compounds including their synthesis.
Keywords: Thiazolidinediones, antidiabetic compounds, glitazones, compounds, diabetes mellitus, hyperglycemia, cell, PPAR receptor, Troglitazone, Rezulin, alanine aminotransferase, hepatotoxicity, carboxylic acids, thiourea, hypolipidemic activity, Ciglitazone, diazonium chloride, englitazone, sodium methoxide, benzofuran thiazolidinediones, sulfonylureas, metformin, glucosidase inhibitors, vinylarene, diazonium bromide, bromopropionate, Rosiglitazone, Netoglitazone, Rivoglitazone, lobeglitazone
Current Organic Chemistry
Title: Synthetic Thiazolidinediones: Potential Antidiabetic Compounds
Volume: 15 Issue: 1
Author(s): Aurelio Ortiz and Estibaliz Sansinenea
Affiliation:
Keywords: Thiazolidinediones, antidiabetic compounds, glitazones, compounds, diabetes mellitus, hyperglycemia, cell, PPAR receptor, Troglitazone, Rezulin, alanine aminotransferase, hepatotoxicity, carboxylic acids, thiourea, hypolipidemic activity, Ciglitazone, diazonium chloride, englitazone, sodium methoxide, benzofuran thiazolidinediones, sulfonylureas, metformin, glucosidase inhibitors, vinylarene, diazonium bromide, bromopropionate, Rosiglitazone, Netoglitazone, Rivoglitazone, lobeglitazone
Abstract: Type 2 diabetes mellitus is a growing health problem across the world. Thiazolidinediones, a new class of oral antidiabetic agents, appear to be ideally suited for the treatment of this disease. The examination of the clinical efficacy of different thiazolidinediones has been extensive. This review summarizes the current state of the cut concerning the clinical use of different thiazolidinediones, starting from the first synthetic thiazolidinediones to the recently developed glitazones. A main focus of this review is the description of the chemistry of these compounds including their synthesis.
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Cite this article as:
Ortiz Aurelio and Sansinenea Estibaliz, Synthetic Thiazolidinediones: Potential Antidiabetic Compounds, Current Organic Chemistry 2011; 15 (1) . https://dx.doi.org/10.2174/138527211793797774
DOI https://dx.doi.org/10.2174/138527211793797774 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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