Resident and Non-Resident Stem Cells in Acute Myocardial Infarction

Title: Resident and Non-Resident Stem Cells in Acute Myocardial Infarction

Volume: 10 Issue: 3

Author(s): Noela Rodriguez-Losada, Manuel F. Jimenez-Navarro, Borja Fernandez, Carmen Rueda-Martinez, Antonia Aranega, Juan A. Marchal and Eduardo de Teresa Galvan

Affiliation:

Keywords: Resident stem cells, cardiovascular disease, endothelial progenitor cells, acute myocardial infarction.

Abstract: Cardiovascular disease is the leading cause of death in developed countries. Acute myocardial infarction (AMI) is the result of hypoxia leading to cardiomyocyte death. This causes loss of function of contractile tissue, which is replaced by non-contractile fibrous tissue affecting left ventricular ejection fraction (LVEF).

One of the current approaches to recover LVEF after an AMI is focused on the search for functional cells to replace the dead tissue, via implantation in the heart of autologous progenitor cells with a regenerative capacity. This review classifies these cells into two types: a) non-resident cells and b) resident cells within the cardiac tissue. We provide an overall view of the various subpopulations and their markers, based, in humans and animal models from the early pioneering work to the latest findings.

Cite this article as:

Rodriguez-Losada Noela, F. Jimenez-Navarro Manuel, Fernandez Borja, Rueda-Martinez Carmen, Aranega Antonia, A. Marchal Juan and de Teresa Galvan Eduardo, Resident and Non-Resident Stem Cells in Acute Myocardial Infarction, Cardiovascular & Hematological Disorders-Drug Targets 2010; 10 (3) . https://dx.doi.org/10.2174/1871529X11006030202