Abstract
Chelation therapy occupies a central place in modern medicine and pharmacology, because continuous studies with laboratory animals and extensive clinical experience demonstrate that acute or chronic intoxications with a variety of metals can be considerable improved by administration of a suitable chelating agent. In this review the chemical characteristics, properties and uses of the most common chelating agents as well as those of some new and very promising agents of this type, are discussed. In the second part of the review the biological and biochemical impact of these agents, as well as their use for the treatment of some selected diseases and disorders, are also analyzed and discussed in detail.
Keywords: Toxic metals, chelating agents, chemical characteristics, biological effects, Chelation Therapies, Bioinorganic Chemistry, biolixiviation, remediation, decon-tamination, metal-based drugs, Bertrand diagram, chelation therapy, ligand-to-metal interaction, hard-soft acid-base concept (HSAB), non-essential toxic elements, 2,3-dimercaptopropanol (BAL), Ethylenediaminetetraacetic acid (EDTA), hypocalcemia, nephrotoxic, atherosclerosis, DTPA, CDTA, TTHA, Polyaminopolycarboxylic Acids, Monoalkyl Esters of DMSA, Lipoic Acid (LA), Dihydrolipoic Acid (DHLA), Metal Intoxications, potentiate cadmium toxicity, Vanadium Toxicity, polyaminopolyarboxylic acids, Alzheimer disease, Wilson Disease, Cu/metallothionein, D-penicillamine, nephritic syndrome, autoimmune reactions, (TETA), Desferrioxamine B, deferiprone, deferasirox, macrophages, hepatocytes, plaques, Parkinson's disease, Huntington's disease, blood-brain-barrier, metal-protein attenuating compound (MPAC), clioquinol (CQ), 2-2'-methilenedi-8-quinolinol
Current Medicinal Chemistry
Title: Chelation Therapies: A Chemical and Biochemical Perspective
Volume: 17 Issue: 31
Author(s): E. J. Baran
Affiliation:
Keywords: Toxic metals, chelating agents, chemical characteristics, biological effects, Chelation Therapies, Bioinorganic Chemistry, biolixiviation, remediation, decon-tamination, metal-based drugs, Bertrand diagram, chelation therapy, ligand-to-metal interaction, hard-soft acid-base concept (HSAB), non-essential toxic elements, 2,3-dimercaptopropanol (BAL), Ethylenediaminetetraacetic acid (EDTA), hypocalcemia, nephrotoxic, atherosclerosis, DTPA, CDTA, TTHA, Polyaminopolycarboxylic Acids, Monoalkyl Esters of DMSA, Lipoic Acid (LA), Dihydrolipoic Acid (DHLA), Metal Intoxications, potentiate cadmium toxicity, Vanadium Toxicity, polyaminopolyarboxylic acids, Alzheimer disease, Wilson Disease, Cu/metallothionein, D-penicillamine, nephritic syndrome, autoimmune reactions, (TETA), Desferrioxamine B, deferiprone, deferasirox, macrophages, hepatocytes, plaques, Parkinson's disease, Huntington's disease, blood-brain-barrier, metal-protein attenuating compound (MPAC), clioquinol (CQ), 2-2'-methilenedi-8-quinolinol
Abstract: Chelation therapy occupies a central place in modern medicine and pharmacology, because continuous studies with laboratory animals and extensive clinical experience demonstrate that acute or chronic intoxications with a variety of metals can be considerable improved by administration of a suitable chelating agent. In this review the chemical characteristics, properties and uses of the most common chelating agents as well as those of some new and very promising agents of this type, are discussed. In the second part of the review the biological and biochemical impact of these agents, as well as their use for the treatment of some selected diseases and disorders, are also analyzed and discussed in detail.
Export Options
About this article
Cite this article as:
J. Baran E., Chelation Therapies: A Chemical and Biochemical Perspective, Current Medicinal Chemistry 2010; 17 (31) . https://dx.doi.org/10.2174/092986710793213760
DOI https://dx.doi.org/10.2174/092986710793213760 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
Current advances in inherited cardiomyopathy
Describe in detail all novel advances in multimodality imaging related to inherited cardiomyopathy diagnosis and prognosis. Shed light to deeper phenotypic characterization. Acknowledge recent advances in genetics, genomics and precision medicineread more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Paradoxes of Symmetry: Homochirality; Cryptochiral Reactions; Chiral Field, Memory, and Induction; Chiral and Racemic Environment
Current Organic Chemistry Kaiso Protein in the Regulation of Brain and Behavior
Current Protein & Peptide Science Potential Therapeutic Effects of Exercise to the Brain
Current Medicinal Chemistry Crosstalk Between the Angiotensin and Endothelin-System in the Cerebrovasculature
Current Neurovascular Research Heterocyclic Analogues as Kinase Inhibitors: A Focus Review
Current Topics in Medicinal Chemistry Metabotropic Glutamate Receptors in Central Nervous System Diseases
Current Drug Targets Classical Neurotransmitters and Neuropeptides Involved in Schizophrenia: How to Choose the Appropriate Antipsychotic Drug?
Current Drug Therapy Cucurbitacin E, An Experimental Lead Triterpenoid with Anticancer, Immunomodulatory and Novel Effects Against Degenerative Diseases. A Mini-Review
Current Topics in Medicinal Chemistry Characteristics of Insulin-degrading Enzyme in Alzheimer's Disease: A Meta-Analysis
Current Alzheimer Research It is All About Proteases: From Drug Delivery to In Vivo Imaging and Photomedicine
Current Medicinal Chemistry The Role of Atypical Antipsychotics in Sexuality: Road to Recovery in Schizophrenia
Current Drug Targets Progranulin Mutations in Ubiquitin-Positive Frontotemporal Dementia Linked to Chromosome 17q21
Current Alzheimer Research Targeting the Noradrenergic System in Posttraumatic Stress Disorder: A Systematic Review and Meta-Analysis of Prazosin Trials
Current Drug Targets Tartaric Acid Enhances Adrenergic Receptor Activity: Test of a General Theory of Extracellular Aminergic GPCR Enhancer Discovery
Current Drug Discovery Technologies Embryonic Stem Cells or Induced Pluripotent Stem Cells? A DNA Integrity Perspective
Current Gene Therapy Exploring the Role of Aggregated Proteomes in the Pathogenesis of Alzheimer’s Disease
Current Protein & Peptide Science Stem Cell Therapy in Heart Diseases: A Review of Selected New Perspectives,Practical Considerations and Clinical Applications
Current Cardiology Reviews Involvement of the Blood-Brain Barrier in Metabolic Regulation
CNS & Neurological Disorders - Drug Targets Specific Roles of NMDA Receptor Subunits in Mental Disorders
Current Molecular Medicine Astaxanthin; a Promising Protector Against Gentamicin-Induced Nephrotoxicity in Rats
Current Pharmaceutical Biotechnology