Abstract
This paper will focus on understanding the role and action of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in the molecular and biochemical pathways responsible for the regulation of the survival of hair cells and spiral ganglion neurons in the auditory portion of the inner ear. The pivotal role of ROS/RNS in ototoxicity makes them potentially valuable candidates for effective otoprotective strategies. In this review, we describe the major characteristics of ROS/RNS and the different oxidative processes observed during ototoxic cascades. At each step, we discuss their potential as therapeutic targets because an increasing number of compounds that modulate ROS/RNS processing or targets are being identified.
Keywords: Reactive oxygen species, ototoxicity, aminoglycoside, cisplatin, noise, presbycusis, cochlea, Oxidative Stress, nitro-gen species (RNS), reactive oxygen species (ROS), reactive, spiral ganglion neurons, primary auditory neurons, superoxide dismutase (SOD), enzymatic metabolism, sory neurons, neurotransmission, lipopolysaccharide, aminoglycosides, immunoreactivity, spiral limbus, modiolus, Glutathione, Xanthine oxidase activity, Thioredoxin reductase 1 (TxR1), Noise Trauma, Genetic Interventions, Antioxidant Enzymes, Oxidant Scavengers, Metal Chelators, thioredoxin
Current Medicinal Chemistry
Title: Oxidative Stress in the Cochlea: An Update
Volume: 17 Issue: 30
Author(s): A. L. Poirrier, J. Pincemail, P. Van Den Ackerveken, P. P. Lefebvre and B. Malgrange
Affiliation:
Keywords: Reactive oxygen species, ototoxicity, aminoglycoside, cisplatin, noise, presbycusis, cochlea, Oxidative Stress, nitro-gen species (RNS), reactive oxygen species (ROS), reactive, spiral ganglion neurons, primary auditory neurons, superoxide dismutase (SOD), enzymatic metabolism, sory neurons, neurotransmission, lipopolysaccharide, aminoglycosides, immunoreactivity, spiral limbus, modiolus, Glutathione, Xanthine oxidase activity, Thioredoxin reductase 1 (TxR1), Noise Trauma, Genetic Interventions, Antioxidant Enzymes, Oxidant Scavengers, Metal Chelators, thioredoxin
Abstract: This paper will focus on understanding the role and action of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in the molecular and biochemical pathways responsible for the regulation of the survival of hair cells and spiral ganglion neurons in the auditory portion of the inner ear. The pivotal role of ROS/RNS in ototoxicity makes them potentially valuable candidates for effective otoprotective strategies. In this review, we describe the major characteristics of ROS/RNS and the different oxidative processes observed during ototoxic cascades. At each step, we discuss their potential as therapeutic targets because an increasing number of compounds that modulate ROS/RNS processing or targets are being identified.
Export Options
About this article
Cite this article as:
L. Poirrier A., Pincemail J., Van Den Ackerveken P., P. Lefebvre P. and Malgrange B., Oxidative Stress in the Cochlea: An Update, Current Medicinal Chemistry 2010; 17 (30) . https://dx.doi.org/10.2174/092986710792927895
DOI https://dx.doi.org/10.2174/092986710792927895 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the treatment of chronic inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
The Epidemiological, Mechanistic and Potential Clinical Role of Androgen Receptor (AR) in Urothelial Carcinoma
Current Drug Targets Dehydroepiandrosterone and Its Derivatives: Potentially Novel Anti-Proliferative and Chemopreventive Agents
Current Pharmaceutical Design Oxidative Stress, Redox Signaling and Cancer Chemoresistance: Putting Together the Pieces of the Puzzle
Current Medicinal Chemistry The Integral Nuclear Membrane Protein Nurim Plays a Role in the Suppression of Apoptosis
Current Molecular Medicine Editorial (Thematic Issue: “miRNA and Cancer; Computational and Experimental Approaches”)
Current Pharmaceutical Biotechnology Viruses in Semen and Male Genital Tissues - Consequences for the Reproductive System and Therapeutic Perspectives
Current Pharmaceutical Design Epigenetic Effects of Environmental Chemicals on Reproductive Biology
Current Drug Targets Novel Approaches in the Synthesis of Batracylin and Its Analogs: Rebirth of an Old Player?
Current Medicinal Chemistry Safety and Side Effects of Cannabidiol, a Cannabis sativa Constituent
Current Drug Safety Cadmium and Its Epigenetic Effects
Current Medicinal Chemistry Impact of Environmental Toxicants on Testicular Function
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued) Identification of AHSA1 as a Potential Therapeutic Target for Breast Cancer: Bioinformatics Analysis and <i>in vitro</i> Studies
Current Cancer Drug Targets A Neuroinformatics Study Describing Molecular Interaction of Cisplatin with Acetylcholinesterase: A Plausible Cause for Anticancer Drug Induced Neurotoxicity
CNS & Neurological Disorders - Drug Targets Potentials of Hydrogels in Cancer Therapy
Current Cancer Therapy Reviews Relevance of Aromatase Inhibitors in Breast Cancer Treatment
Current Topics in Medicinal Chemistry The Impact of Thrombopoietin on Clinical Practice
Current Pharmaceutical Design Drug-Induced Peripheral Neuropathy: Diagnosis and Management
Current Cancer Drug Targets CYP2A5 Induction and Hepatocellular Stress: An Adaptive Response to Perturbations of Heme Homeostasis
Current Drug Metabolism Management of Ovarian Cancer In Younger Women
Reviews on Recent Clinical Trials Cytochrome P450 in the Brain ; A Review
Current Drug Metabolism