Abstract
In the last decades, the treatment of obsessive-compulsive disorder (OCD) has been revolutioned by the introduction into the clinical practice of the selective serotonin (5-HT) reuptake inhibitors (SSRIs), following the observation of the unique response of OCD patients to clomipramine. However, if with no doubt the 5-HT system is central to the pharmacological treatment of OCD, it is unlikely that it represents the whole story. In fact, different studies suggest abnormalities of other neurotransmitters, neuropeptides or second messengers, so that it can be hypothesized that the possible heterogeneity of pathophysiological mechanisms might underlie the different clinical pictures and responses to treatment. Moreover, latest developments in the pharmacology of SSRIs have shown that they share the common property of 5-HT reuptake blockade, but, with the exception of citalopram and escitalopram, they do interact with other receptors and systems. In this paper, the latest findings on pharmacological treatments of OCD will be reviewed, together with a focus on putative targets for future drugs, such as the glutamate system or second messengers, and the problems related to treating OCD in different ages.
Keywords: Obsessive-compulsive disorder, pharmacological treatment, antidepressants, clomipramine, selective serotonin reuptake inhibitors, resistance, anti-obsessive new compounds, Obsessions, Compulsions, anxiety, symptoms, tricyclic antidepressant, pathophysiology, ECA survey, psychotherapy, (ERP), Y-BOCS, chronic, agitation, insomnia, nausea, gastro-intestinal distress, (rTMS), dorsolateral prefrontal cortex, deep brain stimulation, neurosurgery, bilateral ante-rior capsulotomy, cingulotomy, leucotomy, subcaudate tractotomy, inositol, D-cycloserine, riluzole, morphine, cyto-chrome P450, Fluvoxamine, Fluoxetine, Sertraline, Paroxetine, Citalopram, Escitalopram, (SNRIs), Venlafaxine, Duloxetine, Pindolol, (SPECT), N-methyl-D-aspartate, Memantine, egodystonia, PANDAS, augmentation
Current Medicinal Chemistry
Title: Past, Present and Future Drugs for the Treatment of Obsessive- Compulsive Disorder
Volume: 17 Issue: 29
Author(s): D. Marazziti, G. Consoli, S. Baroni and M. Catena Dell'Osso
Affiliation:
Keywords: Obsessive-compulsive disorder, pharmacological treatment, antidepressants, clomipramine, selective serotonin reuptake inhibitors, resistance, anti-obsessive new compounds, Obsessions, Compulsions, anxiety, symptoms, tricyclic antidepressant, pathophysiology, ECA survey, psychotherapy, (ERP), Y-BOCS, chronic, agitation, insomnia, nausea, gastro-intestinal distress, (rTMS), dorsolateral prefrontal cortex, deep brain stimulation, neurosurgery, bilateral ante-rior capsulotomy, cingulotomy, leucotomy, subcaudate tractotomy, inositol, D-cycloserine, riluzole, morphine, cyto-chrome P450, Fluvoxamine, Fluoxetine, Sertraline, Paroxetine, Citalopram, Escitalopram, (SNRIs), Venlafaxine, Duloxetine, Pindolol, (SPECT), N-methyl-D-aspartate, Memantine, egodystonia, PANDAS, augmentation
Abstract: In the last decades, the treatment of obsessive-compulsive disorder (OCD) has been revolutioned by the introduction into the clinical practice of the selective serotonin (5-HT) reuptake inhibitors (SSRIs), following the observation of the unique response of OCD patients to clomipramine. However, if with no doubt the 5-HT system is central to the pharmacological treatment of OCD, it is unlikely that it represents the whole story. In fact, different studies suggest abnormalities of other neurotransmitters, neuropeptides or second messengers, so that it can be hypothesized that the possible heterogeneity of pathophysiological mechanisms might underlie the different clinical pictures and responses to treatment. Moreover, latest developments in the pharmacology of SSRIs have shown that they share the common property of 5-HT reuptake blockade, but, with the exception of citalopram and escitalopram, they do interact with other receptors and systems. In this paper, the latest findings on pharmacological treatments of OCD will be reviewed, together with a focus on putative targets for future drugs, such as the glutamate system or second messengers, and the problems related to treating OCD in different ages.
Export Options
About this article
Cite this article as:
Marazziti D., Consoli G., Baroni S. and Catena Dell'Osso M., Past, Present and Future Drugs for the Treatment of Obsessive- Compulsive Disorder, Current Medicinal Chemistry 2010; 17 (29) . https://dx.doi.org/10.2174/092986710793176384
DOI https://dx.doi.org/10.2174/092986710793176384 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
Call for Papers in Thematic Issues
Advances in Medicinal Chemistry: From Cancer to Chronic Diseases.
The broad spectrum of the issue will provide a comprehensive overview of emerging trends, novel therapeutic interventions, and translational insights that impact modern medicine. The primary focus will be diseases of global concern, including cancer, chronic pain, metabolic disorders, and autoimmune conditions, providing a broad overview of the advancements in ...read more
Approaches to the treatment of chronic inflammation
Chronic inflammation is a hallmark of numerous diseases, significantly impacting global health. Although chronic inflammation is a hot topic, not much has been written about approaches to its treatment. This thematic issue aims to showcase the latest advancements in chronic inflammation treatment and foster discussion on future directions in this ...read more
Cellular and Molecular Mechanisms of Non-Infectious Inflammatory Diseases: Focus on Clinical Implications
The Special Issue covers the results of the studies on cellular and molecular mechanisms of non-infectious inflammatory diseases, in particular, autoimmune rheumatic diseases, atherosclerotic cardiovascular disease and other age-related disorders such as type II diabetes, cancer, neurodegenerative disorders, etc. Review and research articles as well as methodology papers that summarize ...read more
Chalcogen-modified nucleic acid analogues
Chalcogen-modified nucleosides, nucleotides and oligonucleotides have been of great interest to scientific research for many years. The replacement of oxygen in the nucleobase, sugar or phosphate backbone by chalcogen atoms (sulfur, selenium, tellurium) gives these biomolecules unique properties resulting from their altered physical and chemical properties. The continuing interest in ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Inflammatory Caspases: Targets for Novel Therapies
Current Pharmaceutical Design Impaired DNA Damage Repair as a Common Feature of Neurodegenerative Diseases and Psychiatric Disorders
Current Molecular Medicine Epidemiology and Etiology of Alzheimer’s disease: From Genetic to Non- Genetic Factors
Current Alzheimer Research RNA Therapeutics Directed to the Non Coding Regions of APP mRNA, In Vivo Anti-Amyloid Efficacy of Paroxetine, Erythromycin, and N-acetyl cysteine
Current Alzheimer Research Tetracyclines: Drugs with Huge Therapeutic Potential
Mini-Reviews in Medicinal Chemistry Polyphenols Beyond Barriers: A Glimpse into the Brain
Current Neuropharmacology Single Amino Acid Repeats Connect Viruses to Neurodegeneration
Current Drug Discovery Technologies P2Y Receptors in the Mammalian Nervous System: Pharmacology, Ligands and Therapeutic Potential
CNS & Neurological Disorders - Drug Targets Editorial: Structural Aspects of Protein Aggregation
Protein & Peptide Letters JNK Signalling: A Possible Target to Prevent Neurodegeneration
Current Pharmaceutical Design Axotomy Leads to Reduced Calcium Increase and Earlier Termination of CCL2 Release in Spinal Motoneurons with Upregulated Parvalbumin Followed by Decreased Neighboring Microglial Activation
CNS & Neurological Disorders - Drug Targets New Kid on the Block: Does Histamine Get Along with Inflammation in Amyotrophic Lateral Sclerosis?
CNS & Neurological Disorders - Drug Targets Glaucoma and Aging
Current Aging Science Crystal Structure of a Cu,Zn Superoxide Dismutase From the Thermophilic Fungus <i>Chaetomium thermophilum</i>
Protein & Peptide Letters Molecular Chaperone ORP150 in ER Stress–related Diseases
Current Pharmaceutical Design Parkinson Disease Genetics: A "Continuum" from Mendelian to Multifactorial Inheritance
Current Molecular Medicine The Identification and Characterization of Excitotoxic Nerve-endings in Alzheimer Disease
Current Alzheimer Research Bridging Over the Troubled Heterogeneity of SPG-Related Pathologies: Mechanisms Unite What Genetics Divide
Current Molecular Medicine Application of Contemporary Neuroproteomic Techniques in Unravelling Neurological Disorders
Current Protein & Peptide Science Galectin-1 as a Potential Therapeutic Agent for Amyotrophic Lateral Sclerosis
Current Drug Targets