Abstract
The anodic voltammetric behavior and electroanalytical determination of rosiglitazone were studied using cyclic, linear sweep, differential pulse and square wave voltammetric techniques on a glassy carbon electrode. The oxidation of rosiglitazone was irreversible and exhibited diffusion controlled process depending on pH. Different parameters were tested to optimize the conditions for the determination of the oxidation mechanism of rosiglitazone. The dependence of current intensities and potentials on pH, concentration, scan rate, nature of the buffer was also investigated. According to the linear relationship between the peak current and the concentration, differential pulse and square wave voltammetric methods for rosiglitazone assay in pharmaceutical dosage forms and biological fluids were developed. A linear response was obtained within the range of 1x10-6M – 6x10-5M in 0.1 M H2SO4 and acetate buffer at pH 5.70 for both voltammetric methods in human serum samples. The practical analytical value of the method was demonstrated by quantitative determination of rosiglitazon in pharmaceutical formulation and human serum, without the need for separation or complex sample preparation, since there was no interference from the excipients and endogenous substances. The methods were fully validated and successfully applied to the high throughput determination of the drug in tablets and human serum with good recoveries.
Keywords: Rosiglitazone, voltammetry, pharmaceuticals, serum samples, glassy carbon electrode, oxidation
Combinatorial Chemistry & High Throughput Screening
Title: Anodic Voltammetric Behavior and Determination of Rosiglitazone in Pharmaceutical Dosage Forms and Biological Fluids on Solid Electrode
Volume: 13 Issue: 8
Author(s): Burcu Dogan-Topal, Secil Tuncel and Sibel A. Ozkan
Affiliation:
Keywords: Rosiglitazone, voltammetry, pharmaceuticals, serum samples, glassy carbon electrode, oxidation
Abstract: The anodic voltammetric behavior and electroanalytical determination of rosiglitazone were studied using cyclic, linear sweep, differential pulse and square wave voltammetric techniques on a glassy carbon electrode. The oxidation of rosiglitazone was irreversible and exhibited diffusion controlled process depending on pH. Different parameters were tested to optimize the conditions for the determination of the oxidation mechanism of rosiglitazone. The dependence of current intensities and potentials on pH, concentration, scan rate, nature of the buffer was also investigated. According to the linear relationship between the peak current and the concentration, differential pulse and square wave voltammetric methods for rosiglitazone assay in pharmaceutical dosage forms and biological fluids were developed. A linear response was obtained within the range of 1x10-6M – 6x10-5M in 0.1 M H2SO4 and acetate buffer at pH 5.70 for both voltammetric methods in human serum samples. The practical analytical value of the method was demonstrated by quantitative determination of rosiglitazon in pharmaceutical formulation and human serum, without the need for separation or complex sample preparation, since there was no interference from the excipients and endogenous substances. The methods were fully validated and successfully applied to the high throughput determination of the drug in tablets and human serum with good recoveries.
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Cite this article as:
Dogan-Topal Burcu, Tuncel Secil and A. Ozkan Sibel, Anodic Voltammetric Behavior and Determination of Rosiglitazone in Pharmaceutical Dosage Forms and Biological Fluids on Solid Electrode, Combinatorial Chemistry & High Throughput Screening 2010; 13 (8) . https://dx.doi.org/10.2174/138620710791920419
DOI https://dx.doi.org/10.2174/138620710791920419 |
Print ISSN 1386-2073 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5402 |
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