Abstract
During normal nervous system development, physiologically appropriate neuronal apoptosis contributes to a sculpting process that removes approximately one-half of all neurons born during neurogenesis. However, neuronal apoptosis subsequent to this developmental window is physiologically inappropriate for most systems and can contribute to neurodegenerative diseases. Neuronal apoptosis is characterized by specific morphological events and requires the activation of an intrinsic transcriptional program. With the completion of genome sequencing in humans and model organisms, and the advent of DNA microarray technology, the transcriptional cascades and networks regulating neuronal apoptosis are being elucidated providing new potential pharmacological targets. This review will introduce the reader to this genomic approach and illustrate with a few examples a methodological strategy for the rational selection of pharmacological targets and the development of neuroprotective agents.
Keywords: Apoptosis, drug, neuronal, pharmacogenomics, programmed cell death, systems biology, target
Current Medicinal Chemistry
Title: Drug Target Identification for Neuronal Apoptosis Through a Genome Scale Screening
Volume: 17 Issue: 26
Author(s): E.A. Tendi, R. Cunsolo, D. Bellia, R.L. Messina, S. Paratore, P. Calissano and S. Cavallaro
Affiliation:
Keywords: Apoptosis, drug, neuronal, pharmacogenomics, programmed cell death, systems biology, target
Abstract: During normal nervous system development, physiologically appropriate neuronal apoptosis contributes to a sculpting process that removes approximately one-half of all neurons born during neurogenesis. However, neuronal apoptosis subsequent to this developmental window is physiologically inappropriate for most systems and can contribute to neurodegenerative diseases. Neuronal apoptosis is characterized by specific morphological events and requires the activation of an intrinsic transcriptional program. With the completion of genome sequencing in humans and model organisms, and the advent of DNA microarray technology, the transcriptional cascades and networks regulating neuronal apoptosis are being elucidated providing new potential pharmacological targets. This review will introduce the reader to this genomic approach and illustrate with a few examples a methodological strategy for the rational selection of pharmacological targets and the development of neuroprotective agents.
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Cite this article as:
Tendi E.A., Cunsolo R., Bellia D., Messina R.L., Paratore S., Calissano P. and Cavallaro S., Drug Target Identification for Neuronal Apoptosis Through a Genome Scale Screening, Current Medicinal Chemistry 2010; 17 (26) . https://dx.doi.org/10.2174/092986710792065081
DOI https://dx.doi.org/10.2174/092986710792065081 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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