Abstract
Computational modeling techniques and computer simulations have become a routine in biological sciences and have gained great attention from researchers. Molecular dynamics simulation is a valuable tool towards an understanding of the complex structure of biological systems, especially in the study of the flexibility of the biological molecules such as peptides or proteins. Peptides play a very important role in human physiology and control many of the processes involved in the immune system response. Designing new and optimal peptide vaccines is one of the hottest challenges of the 21st century science and it brings together researchers from different fields. Molecular dynamics simulations have proven to be a helpful tool assisting laboratory work, saving financial sources and opening possibilities for exploring properties of the molecular systems that are hardly accessible by conventional experimental methods. Present review is dedicated to the recent contributions in applications of molecular dynamics simulations in peptide design for immunological purposes, such as B or T cell epitopes.
Keywords: B cell, T cell, TCR, complement system, computer simulation, MHC, antigen, antibody, antibody-antigen interactions, epitope, molecular dynamics, epitope prediction, vaccine design
Current Computer-Aided Drug Design
Title: Conformational Flexibility in Designing Peptides for Immunology: The Molecular Dynamics Approach
Volume: 6 Issue: 3
Author(s): Athanassios Stavrakoudis
Affiliation:
Keywords: B cell, T cell, TCR, complement system, computer simulation, MHC, antigen, antibody, antibody-antigen interactions, epitope, molecular dynamics, epitope prediction, vaccine design
Abstract: Computational modeling techniques and computer simulations have become a routine in biological sciences and have gained great attention from researchers. Molecular dynamics simulation is a valuable tool towards an understanding of the complex structure of biological systems, especially in the study of the flexibility of the biological molecules such as peptides or proteins. Peptides play a very important role in human physiology and control many of the processes involved in the immune system response. Designing new and optimal peptide vaccines is one of the hottest challenges of the 21st century science and it brings together researchers from different fields. Molecular dynamics simulations have proven to be a helpful tool assisting laboratory work, saving financial sources and opening possibilities for exploring properties of the molecular systems that are hardly accessible by conventional experimental methods. Present review is dedicated to the recent contributions in applications of molecular dynamics simulations in peptide design for immunological purposes, such as B or T cell epitopes.
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Cite this article as:
Stavrakoudis Athanassios, Conformational Flexibility in Designing Peptides for Immunology: The Molecular Dynamics Approach, Current Computer-Aided Drug Design 2010; 6 (3) . https://dx.doi.org/10.2174/157340910791760073
DOI https://dx.doi.org/10.2174/157340910791760073 |
Print ISSN 1573-4099 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6697 |
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