Abstract
MicroRNA-21 (miR-21) expression is activated in multiple types of cancers, such as breast, liver, brain, prostate, myometrial cancers but also in cardiovascular disease. MiR-21 regulates a plethora of target proteins which are involved in cellular survival, apoptosis and cell invasiveness. MiR-21 regulation is complex due to an own promoter that is target for various transcription factors and hormones. The consistent miR-21 overexpression under pathophysiological conditions points to miR-21 as a valuable tool for new therapeutic strategies. In this review, we present and analyze current data about miR-21 expression in various pathologies ranging from cancer to cardiovascular disease. Further, miR- 21 regulatory mechanisms and miR-21 downstream targets are discussed. Finally, we highlight the particular role of miR- 21 as a therapeutic target in various diseases.
Keywords: micro-RNAs, miR-21, cancer, cardiovascular disease
Current Drug Targets
Title: MicroRNA-21: From Cancer to Cardiovascular Disease
Volume: 11 Issue: 8
Author(s): Virginija Jazbutyte and Thomas Thum
Affiliation:
Keywords: micro-RNAs, miR-21, cancer, cardiovascular disease
Abstract: MicroRNA-21 (miR-21) expression is activated in multiple types of cancers, such as breast, liver, brain, prostate, myometrial cancers but also in cardiovascular disease. MiR-21 regulates a plethora of target proteins which are involved in cellular survival, apoptosis and cell invasiveness. MiR-21 regulation is complex due to an own promoter that is target for various transcription factors and hormones. The consistent miR-21 overexpression under pathophysiological conditions points to miR-21 as a valuable tool for new therapeutic strategies. In this review, we present and analyze current data about miR-21 expression in various pathologies ranging from cancer to cardiovascular disease. Further, miR- 21 regulatory mechanisms and miR-21 downstream targets are discussed. Finally, we highlight the particular role of miR- 21 as a therapeutic target in various diseases.
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Cite this article as:
Jazbutyte Virginija and Thum Thomas, MicroRNA-21: From Cancer to Cardiovascular Disease, Current Drug Targets 2010; 11 (8) . https://dx.doi.org/10.2174/138945010791591403
DOI https://dx.doi.org/10.2174/138945010791591403 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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