Abstract
About 35 years ago human papillomaviruses (HPV) have been suggested as causative agent for cervical cancer whose infectious etiology had been suggested already many years before. The discovery of the plurality of HPVs encompassing a variety of types with particular biologic properties, the regular presence of the genomes of the so called high-risk types within tumor biopsies, the awareness about the transforming potential of the viral proteins and informative epidemiological surveys led to the consenting view of a causative link between these viruses and cervical cancer and ultimately triggered the development of HPV-specific vaccines for prevention of cervical cancer.
Keywords: Papillomaviruses, heterogeneity, cervical cancer, molecular cloning, epidemiology
Current Cancer Therapy Reviews
Title: The Discovery of HPV and its Clinical Implications
Volume: 6 Issue: 2
Author(s): Lutz Gissmann
Affiliation:
Keywords: Papillomaviruses, heterogeneity, cervical cancer, molecular cloning, epidemiology
Abstract: About 35 years ago human papillomaviruses (HPV) have been suggested as causative agent for cervical cancer whose infectious etiology had been suggested already many years before. The discovery of the plurality of HPVs encompassing a variety of types with particular biologic properties, the regular presence of the genomes of the so called high-risk types within tumor biopsies, the awareness about the transforming potential of the viral proteins and informative epidemiological surveys led to the consenting view of a causative link between these viruses and cervical cancer and ultimately triggered the development of HPV-specific vaccines for prevention of cervical cancer.
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Cite this article as:
Gissmann Lutz, The Discovery of HPV and its Clinical Implications, Current Cancer Therapy Reviews 2010; 6 (2) . https://dx.doi.org/10.2174/157339410791202538
DOI https://dx.doi.org/10.2174/157339410791202538 |
Print ISSN 1573-3947 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6301 |
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Current progress in Protein Degradation and Cancer Therapy
argeted Protein Degradation is gaining momentum in cancer therapy, it facilitate targeting undruggable proteins, it overcome cancer resistance and avoid undesirable side effects. Thus small molecules degraders have emerged as novel therapeutic strategy. Targeted protein degradation (TPD), the process of eliminating a protein of interest hold a great promise for ...read more
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