Abstract
Chiral α-monofluorocarbonyl compounds have recently received much attention and have been often employed as targets for asymmetric synthesis. However, there are relatively few reports describing applications of such compounds compared to other types of organofluorine compounds such as trifluoromethylated compounds and fluoroaromatics in spite of the many potential applications of such compounds. We describe here our recent results regarding examination of use of several chiral α-monofluorocarbonyl compounds for determination of absolute configurations of chiral compounds and clarification of biological roles of stereochemistry of important medicinal agents.
Current Organic Chemistry
Title: Application of Chiral α-Monofluorocarbonyl Compounds to Analytical and Medicinal Chemistry
Volume: 14 Issue: 9
Author(s): Tomoya Fujiwara and Yoshio Takeuchi
Affiliation:
Abstract: Chiral α-monofluorocarbonyl compounds have recently received much attention and have been often employed as targets for asymmetric synthesis. However, there are relatively few reports describing applications of such compounds compared to other types of organofluorine compounds such as trifluoromethylated compounds and fluoroaromatics in spite of the many potential applications of such compounds. We describe here our recent results regarding examination of use of several chiral α-monofluorocarbonyl compounds for determination of absolute configurations of chiral compounds and clarification of biological roles of stereochemistry of important medicinal agents.
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Cite this article as:
Fujiwara Tomoya and Takeuchi Yoshio, Application of Chiral α-Monofluorocarbonyl Compounds to Analytical and Medicinal Chemistry, Current Organic Chemistry 2010; 14 (9) . https://dx.doi.org/10.2174/138527210791111803
DOI https://dx.doi.org/10.2174/138527210791111803 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
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