Abstract
In this study, a cell labelling method is presented using biocompatible europium doped hydroxyapatite (Eu-HAP) inorganic nanoparticles. Eu-HAP nanoparticles were successfully prepared by precipitation method and utilized to label Bel-7402 human liver cancer cells as fluorescent probe. After Eu-HAP nanoparticles were internalized by cells, the strong green fluorescence and the red fluorescence were observed with excitation of blue light and green light respectively. Results show that the Eu-HAP nanoparticles exhibit the potential to become valuable biocompatible fluorescent labelling material in biological studies.
Keywords: Europium doped hydroxyapatite, Inorganic nanoparticles, Cell labelling, Fluorescent probe
Current Nanoscience
Title: Biocompatible Europium Doped Hydroxyapatite Nanoparticles as a Biological Fluorescent Probe
Volume: 6 Issue: 2
Author(s): Yingchao Han, Xinyu Wang and Shipu Li
Affiliation:
Keywords: Europium doped hydroxyapatite, Inorganic nanoparticles, Cell labelling, Fluorescent probe
Abstract: In this study, a cell labelling method is presented using biocompatible europium doped hydroxyapatite (Eu-HAP) inorganic nanoparticles. Eu-HAP nanoparticles were successfully prepared by precipitation method and utilized to label Bel-7402 human liver cancer cells as fluorescent probe. After Eu-HAP nanoparticles were internalized by cells, the strong green fluorescence and the red fluorescence were observed with excitation of blue light and green light respectively. Results show that the Eu-HAP nanoparticles exhibit the potential to become valuable biocompatible fluorescent labelling material in biological studies.
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Cite this article as:
Han Yingchao, Wang Xinyu and Li Shipu, Biocompatible Europium Doped Hydroxyapatite Nanoparticles as a Biological Fluorescent Probe, Current Nanoscience 2010; 6 (2) . https://dx.doi.org/10.2174/157341310790945632
DOI https://dx.doi.org/10.2174/157341310790945632 |
Print ISSN 1573-4137 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6786 |
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