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Current Pharmaceutical Biotechnology

Editor-in-Chief

ISSN (Print): 1389-2010
ISSN (Online): 1873-4316

Enhanced Fluorescence of Curcumin on Plasmonic Platforms

Author(s): Anindita Mukerjee, Rafal Luchowski, Amalendu P. Ranjan, Sangram Raut, Jamboor K. Vishwanatha, Zygmunt Gryczynski and Ignacy Gryczynski

Volume 11, Issue 2, 2010

Page: [223 - 228] Pages: 6

DOI: 10.2174/138920110790909623

Price: $65

Abstract

We report a significant increase of a curcumin (1,7-bis[4-hydroxy-3-methoxyphenyl]-1,6-heptadiene-3,5-dione) fluorescence brightness when deposited on plasmonic platforms (self assembled silver nanostructures formed on the surface of silver semitransparent film). The enhancement of fluorescence intensity is accompanied by a strong decrease in fluorescence lifetime. Simultaneously, the increased photostability of curcumin, a pigment showing strong antiinflammatory, antioxidant and antitumorigenic activity, allows long-time detection and monitoring. We believe that the use of plasmonic platforms will improve detection, delivery and imaging of curcumin.

Keywords: Fluorescence lifetime, metal enhanced fluorescence, photostability, plasmonic platforms, brightness, curcumin


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