Abstract
2,3-dihydrobenzo[b][1,4]oxathiine represents a valuable pharmacophoric heterocyclic nucleus known since very long time. Initially, together with some patents reporting the use of these compounds as herbicides or lipogenesis inhibitors, several papers reported their ability as melatonin, histamine and serotonin receptor ligands, α-adrenoreceptor blockers as well as non-glycoside sweeteners. This wide range of biological activities has been recently further improved by studies stating their activity as antimycotics, multi-defense antioxidants and estrogen receptor ligands. The last insights regarding the preparation, the biological activity and the structure activity relationship (SAR) of derivatives containing the dihydrobenzoxathiine skeleton will be discussed in this review.
Keywords: 2,3-Dihydrobenzo[b][1,4]oxathiines, 4-thiaflavanes, sweeteners, antimicotic activity, multi-defense antioxidants, selective estrogen receptor modulators
Current Medicinal Chemistry
Title: Dihydrobenzo[1,4]oxathiine: A Multi-Potent Pharmacophoric Heterocyclic Nucleus
Volume: 17 Issue: 10
Author(s): C. Viglianisi and S. Menichetti
Affiliation:
Keywords: 2,3-Dihydrobenzo[b][1,4]oxathiines, 4-thiaflavanes, sweeteners, antimicotic activity, multi-defense antioxidants, selective estrogen receptor modulators
Abstract: 2,3-dihydrobenzo[b][1,4]oxathiine represents a valuable pharmacophoric heterocyclic nucleus known since very long time. Initially, together with some patents reporting the use of these compounds as herbicides or lipogenesis inhibitors, several papers reported their ability as melatonin, histamine and serotonin receptor ligands, α-adrenoreceptor blockers as well as non-glycoside sweeteners. This wide range of biological activities has been recently further improved by studies stating their activity as antimycotics, multi-defense antioxidants and estrogen receptor ligands. The last insights regarding the preparation, the biological activity and the structure activity relationship (SAR) of derivatives containing the dihydrobenzoxathiine skeleton will be discussed in this review.
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Cite this article as:
Viglianisi C. and Menichetti S., Dihydrobenzo[1,4]oxathiine: A Multi-Potent Pharmacophoric Heterocyclic Nucleus, Current Medicinal Chemistry 2010; 17 (10) . https://dx.doi.org/10.2174/092986710790820697
DOI https://dx.doi.org/10.2174/092986710790820697 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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