Development of an Artificial Chaperone System Based on Cyclodextrin

Title: Development of an Artificial Chaperone System Based on Cyclodextrin

Volume: 11 Issue: 3

Author(s): Yoshihiro Sasaki and Kazunari Akiyoshi

Affiliation:

Keywords: Cyclodextrin, artificial chaperone, surfactant, nanogel, hydrophobized polymer

Abstract: Molecular chaperones in living systems inspired us to explore new concepts for assisting protein refolding. The chaperone selectively interacts with a non-native protein by hydrophobic interaction to prevent irreversible aggregation and releases the protein in its refolded form with the aid of ATP and another co-chaperone. Cyclodextrins have been used to simulate the function of the chaperones by controlling the hydrophobic interaction with proteins. In this chapter, we review the cyclodextrin (CD)-related protein refolding systems.

Cite this article as:

Sasaki Yoshihiro and Akiyoshi Kazunari, Development of an Artificial Chaperone System Based on Cyclodextrin, Current Pharmaceutical Biotechnology 2010; 11 (3) . https://dx.doi.org/10.2174/138920110791111951