Abstract
Ten free-living elderly were administered with a synbiotic [fermented milk containing Lactobacillus rhamnosus Gorbach and Goldin (LGG®)] and oligofructose as a prebiotic for one month. Serum cytokines were evaluated before (T0) and after (T1) synbiotic administration. At T0, values of Interleukin (IL)-12, IL-6, IL-10, IL-1β and Tumor Necrosis Factor (TNF)-α were lower than normal controls, with the exception of IL-8, thus confirming previous results on the impairment of both innate and adaptive responses in elderly. At T1, the synbiotic was able to significantly increase, depressed values of IL-1β, IL-6 and IL-8 with a trend to a modest increase for the restant cytokines. In conclusion, the synbiotic used in this study seems to be very beneficial to elderly for its capacity to maintain the immune homeostasis, even if an increase in dosage and prolongation of administration time are required for a better modulation of the aged adaptive immune response.
Keywords: Cytokines, immunosenescence, Lactobacillus rhamnosus Gorbach and Goldin (LGG®), oligofructose, probiotics, synbiotics, elderly
Current Pharmaceutical Design
Title: Administration of a Synbiotic to Free-Living Elderly and Evaluation of Serum Cytokines. A Pilot Study
Volume: 16 Issue: 7
Author(s): L. Amati, G. Marzulli, M. Martulli, V. Pugliese, C. Caruso, G. Candore, S. Vasto and E. Jirillo
Affiliation:
Keywords: Cytokines, immunosenescence, Lactobacillus rhamnosus Gorbach and Goldin (LGG®), oligofructose, probiotics, synbiotics, elderly
Abstract: Ten free-living elderly were administered with a synbiotic [fermented milk containing Lactobacillus rhamnosus Gorbach and Goldin (LGG®)] and oligofructose as a prebiotic for one month. Serum cytokines were evaluated before (T0) and after (T1) synbiotic administration. At T0, values of Interleukin (IL)-12, IL-6, IL-10, IL-1β and Tumor Necrosis Factor (TNF)-α were lower than normal controls, with the exception of IL-8, thus confirming previous results on the impairment of both innate and adaptive responses in elderly. At T1, the synbiotic was able to significantly increase, depressed values of IL-1β, IL-6 and IL-8 with a trend to a modest increase for the restant cytokines. In conclusion, the synbiotic used in this study seems to be very beneficial to elderly for its capacity to maintain the immune homeostasis, even if an increase in dosage and prolongation of administration time are required for a better modulation of the aged adaptive immune response.
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Cite this article as:
Amati L., Marzulli G., Martulli M., Pugliese V., Caruso C., Candore G., Vasto S. and Jirillo E., Administration of a Synbiotic to Free-Living Elderly and Evaluation of Serum Cytokines. A Pilot Study, Current Pharmaceutical Design 2010; 16 (7) . https://dx.doi.org/10.2174/138161210790883633
DOI https://dx.doi.org/10.2174/138161210790883633 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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